{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:46:57Z","timestamp":1784191617267,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4876,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventy\u2010three pediatric patients with acute hepatitis and 19 control patients without liver disease living in Cairo, Egypt, were evaluated with a newly developed Western blot assay for IgM antibody to hepatitis E virus (IgM anti\u2010HEV). The mean age of acute hepatitis patients was 6.4 years (range, 1\u201013 years); 56% were male. Among the 73 acute cases, hepatitis A was diagnosed in 30 (41%), possible acute hepatitis B in three (4%), hepatitis E in nine (12%), and by exclusion, non\u2010A, non\u2010B hepatitis in 29 (40%). Two additional acute cases were positive for both IgM anti\u2010HAV and IgM anti\u2010HEV. None of the 19 control subjects had IgM anti\u2010HEV. Parenteral risk factors were associated with cases of non\u2010A, non\u2010B hepatitis but were not associated with acute hepatitis E. Contact with a family member with jaundice was associated with acute hepatitis A. In contrast to prior epidemics of enterically\u2010transmitted non\u2010A, non\u2010B hepatitis, HEV was found to be a common cause of acute hepatitis in a pediatric population. This study provides additional evidence that HEV may be a frequent cause of acute sporadic hepatitis among children living in some developing countries. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890370407","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:24:17Z","timestamp":1172870657000},"page":"274-277","source":"Crossref","is-referenced-by-count":48,"title":["Acute sporadic hepatitis E in children living in Cairo, Egypt"],"prefix":"10.1002","volume":"37","author":[{"given":"Kenneth C.","family":"Hyams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Purdyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa M.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Carl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911303212202"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.4269\/ajtmh.1986.35.1040","article-title":"Acute sporadic hepatitis in adults living in Cairo, Egypt","volume":"35","author":"Bassily S","year":"1986","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890160306"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90731-1"},{"key":"e_1_2_1_6_1","first-page":"241","article-title":"Enterically transmitted non\u2010A, non\u2010B hepatitis\u2013East Africa","volume":"36","author":"Centers for Disease Control","year":"1987","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01647001"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"HyamsKC PurdyMA KaurM McCarthyMC HussainMAM ElTiganiA KrawczynskiMK BradleyDW CarlM(1992): Acute sporadic hepatitis E in Sudanese children: analysis based on a new Western blot Assay. 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