{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:10:21Z","timestamp":1698127821210},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4845,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a community study in rural Senegal, 22 human immunodeficiency virus type\u20102 (HIV\u20102) seropositive cases and 64 matched controls were examined clinically and evaluated immunologically. The presence of clinical signs was highly correlated with HIV\u20102 seropositivity: 9 anti\u2010HIV\u20102 positive patients and 5 controls presented with clinical signs (odd ratio [OR] = 8.2, confidence limits [CL] 2\u201035). The main symptom associated with HIV\u20102 seropositivity was a chronic cough (OR = 18.5, CL 1.8\u2010899). The presence of diarrhoea was not significant (OR = 3.1, CL 0.3\u20103.5). The total number of CD8 cells, CD4\/CD8 ratio, \u03b22 microglobulin, and IgG level discriminated between seropositive and seronegative individuals (<jats:italic>P<\/jats:italic> &lt; 0.05). When the anti\u2010HIV\u20102 positives were grouped as 13 healthy and 9 sick people, red blood cells, lymphocytes, T lymphocytes, CD4 cells, and \u03b22 microglobulin differed significantly. Clinical symptoms were associated with immunodepression: 5 of 14 sick people had less than 500 CD4\/\u03bcl vs. 1 of 72 healthy persons. This study at the community level emphasizes the clinical and immunological impact of HIV\u20102 infection. Even if it presents with a longer incubation period than HIV\u20101, this virus is a major threat to public health. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890380114","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:35:39Z","timestamp":1172871339000},"page":"67-70","source":"Crossref","is-referenced-by-count":5,"title":["HIV\u20102 infections in a rural Senegalese community"],"prefix":"10.1002","volume":"38","author":[{"given":"Bernard","family":"Le Guenno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Pison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Enel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Lagarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheikh","family":"Seck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"33","article-title":"AIDS due to HIV\u20102 infection\u2013New Jersey","volume":"37","author":"Center for Disease Control","year":"1988","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2425430"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199005000-00010"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90154-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199003000-00005"},{"key":"e_1_2_1_7_1","first-page":"1168","article-title":"Beta2\u2010microglobulin as a prognostic marker for patients with AIDS in Dar es Salaam, Tanzania","volume":"4","author":"Jorgensen A","year":"1990","journal-title":"AIDS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199011000-00005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91457-7"},{"key":"e_1_2_1_10_1","first-page":"421","article-title":"HIV\u20102 and HIV\u20101 AIDS cases in Senegal: Clinical patterns and immunological perturbations","volume":"4","author":"Le Guenno B","year":"1991","journal-title":"Journal of AIDS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Le GuennoB PisonG EnelC LagardeE SeckC(1992):HIV\u20102 prevalence in three rural regions of Senegal: Low levels and heterogeneous distribution. Transactions of the Royal Society of Tropical Medicine and Hygiene (in press).","DOI":"10.1016\/0035-9203(92)90321-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199012000-00013"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6615.83"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1001\/jama.1986.03380220065023","article-title":"HIV seropreva\u2010lence among hospital workers in Kinshasa, Zaire","volume":"256","author":"Mann J","year":"1986","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1988.4.137"},{"key":"e_1_2_1_16_1","first-page":"88","article-title":"HIV\u20102 associated AIDS and HIV\u20102 seroprevalence in Bissau, Guinea\u2010Bissau","volume":"2","author":"Naucler A","year":"1989","journal-title":"Journal of AIDS"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/330664a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199003000-00001"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890380114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890380114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:52:57Z","timestamp":1698061977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890380114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1002\/jmv.1890380114"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890380114","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}