{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:16:03Z","timestamp":1789985763122,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4815,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the possible relationship of HTLV\u2010I virus infection to autoimmune thyroid disease, we examined, firstly, the frequency of HTLV\u2010I seropositivity among patients with Hashimoto's thyroiditis and, secondly, the frequency of Hashimoto's thyroiditis in patients with HTLV\u2010I associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). Of 144 patients with Hashimoto's thyroiditis in the Tokushima and Kochi Prefectures, Japan, 9 (6.3%) were positive for serum HTLV\u2010I virus antibody 2 of whom were confirmed histologically to have Hashimoto's thyroiditis. This percentage is significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.01) than the estimated prevalence (2.2%) of HTLV\u2010I carriers among the general population in this region. Of 9 patients with HAM\/TSP, 3 (33.3%), including 2 biopsy\u2010proven cases, had evidence of Hashimoto's thyroiditis. This proportion is apparently much higher than the prevalence (1.7%) of Hashimoto's thyroiditis in the general population. These findings suggest that HTLV\u2010I virus may be related to the development of Hashimoto's thyroiditis. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890380212","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:33:30Z","timestamp":1172871210000},"page":"138-141","source":"Crossref","is-referenced-by-count":48,"title":["HTLV\u2010I infection in patients with autoimmune thyroiditis (Hashimoto's thyroiditis)"],"prefix":"10.1002","volume":"38","author":[{"given":"H.","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tsuchihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Niki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90629-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92382-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/341072a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.30.534"},{"key":"e_1_2_1_7_1","first-page":"99","article-title":"HTLV\u2010I associated myelopathy (HAM\u2010TSP) with Hashimoto's thyroiditis","volume":"38","author":"Kawai H","year":"1991","journal-title":"Tokushima Journal of Experimental Medicine"},{"key":"e_1_2_1_8_1","first-page":"672","article-title":"A case report of HTLV\u2010I associated myelopathy (HAM) after pulmonary symptoms and uveitis\u2013relationship between HAM and uveitis","volume":"29","author":"Kashio N","year":"1989","journal-title":"Clinical Neurology (Tokyo)"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115436"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90012-5"},{"key":"e_1_2_1_11_1","first-page":"1","article-title":"Interactions of virus with the immune system","volume":"66","author":"Mims CA","year":"1986","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_1_12_1","first-page":"1085","article-title":"Two families of HTLV\u2010I associated myelopathy","volume":"27","author":"Miyai I","year":"1987","journal-title":"Clinical Neurology (Tokyo)"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91793-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90038-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_1_16_1","first-page":"191","volume-title":"Human Retrovirology HTLV\u2013I","author":"Osame M","year":"1990"},{"key":"e_1_2_1_17_1","unstructured":"OshimoK MikiH TsuyuguchiM MorimotoT InoueH YamashitaY SumiT KomakiK OhmineH KonishiY HaradaK MondenY(1988):Clinical survey of thyroid diseases in Tokushima: Results of 10 year. 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