{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:10:50Z","timestamp":1770988250441,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4754,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of nine oncogenes (c\u2010myc, N\u2010myc, N\u2010ras, H\u2010ras, k\u2010ras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC\/PRF\/5, HepSB, Hep G2, 2.2.15, HLE, and HLF) and in a human embryonic lung fibroblast cell line (WI\u201038) to look for differences that might be associated with the presence (PLC\/PRF\/5, Hep3B, and 2.2.15) or absence (Hep G2, HLE, and HLF) of integrated hepatitis B virus (HBV) DNA. The levels of expression of the oncogenes and tumor suppressor genes were unrelated to the presence or absence of integrated HBV\u2010DNA. Furthermore, the intensity of expression of these oncogenes was no greater in the 2.2.15 cell line (consisting of Hep G2 cells transfected with hepatitis B virus) than in untransfected Hep G2 cells. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890380402","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:49:47Z","timestamp":1172872187000},"page":"235-239","source":"Crossref","is-referenced-by-count":28,"title":["Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines"],"prefix":"10.1002","volume":"38","author":[{"given":"Mahmood","family":"Farshid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Tabor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/282615a0"},{"key":"e_1_2_1_3_1","first-page":"893","article-title":"Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines","volume":"5","author":"Bartek J","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/350429a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.5.1973"},{"key":"e_1_2_1_6_1","first-page":"385","article-title":"Establishment and some biological characteristics of human hepatoma cell lines","volume":"66","author":"Doi I","year":"1975","journal-title":"Gann"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030621"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90045-7"},{"key":"e_1_2_1_9_1","first-page":"13","article-title":"Oncogenes in human primary hepatic cancer","volume":"4","author":"Gu JR","year":"1986","journal-title":"Journal of Cellular Physiology, Supplement"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2838909"},{"key":"e_1_2_1_11_1","first-page":"3067","article-title":"Altered structure and expression of human retinoblastoma susceptibility gene in small cell lung cancer","volume":"50","author":"Hensel CH","year":"1990","journal-title":"Cancer Research"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1988.tb00994.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/jvi.63.2.739-746.1989","article-title":"Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation","volume":"63","author":"Hinds P","year":"1989","journal-title":"Journal of Virology"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/350427a0"},{"key":"e_1_2_1_15_1","first-page":"181","article-title":"Expression of N\u2010ras gene in human primary hepatocarcinoma","volume":"29","author":"Hu LF","year":"1986","journal-title":"Scientia Sinica (B)"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201247"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.205"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)90887-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/jvi.33.2.795-806.1980","article-title":"State of hepatitis B viral DNA in a human hepatoma cell line","volume":"33","author":"Marion PL","year":"1980","journal-title":"Journal of Virology"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.4.1005"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6538699"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91017-4"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350606"},{"key":"e_1_2_1_24_1","first-page":"141","article-title":"Expression of oncogenes in human hepatoma cell lines","volume":"21","author":"Ting LP","year":"1988","journal-title":"Chinese Journal of Microbiology and Immunology"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90971-X"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890380402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890380402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:32:42Z","timestamp":1698053562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890380402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1002\/jmv.1890380402"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890380402","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}