{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:29Z","timestamp":1764996809616},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4572,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A pilot study of chronic hepatitis C treatment was conducted in 14 patients (13 had chronic active hepatitis and 1 had liver cirrhosis). All patients were asymptomatic for the human immunodeficiency virus (HIV) type 1 (mean CD4 count of 584 \u00b1 283 cells\/mm<jats:sup>3<\/jats:sup>). Patients received 9 MU rlFN\u2010\u03b12A per day for three months. After this, patients received 9 MU three times weekly for three months, 6 MU for another three months on the same protocol, and finally 3 MU again three times weekly for the last three months. After the first month of ALT treatment in 9 patients (64%) returned to normal; a significant decrease in ALT levels was observed with respect to the pretreatment values (mean of 42 lU\/l, range 15\u201375 vs 152 IUI, range 69\u2013355; P &lt; 0.01). Of the 9 patients who completed the treatment period, 5 had a complete response, and 4 of these 5 continued with normal ALT values during follow\u2010up (sustained response) while the other patient relapsed within one month after cessation of therapy. The remaining 4 patients were non\u2010responders (including one case with a break\u2010through of the response). HCV\u2010RNA was not detectable in 3 of the 5 responders at the end of therapy while during follow\u2010up viral RNA became undetectable in the other 2 patients. 2\/4 non\u2010responder patients had detectable HCV\u2010RNA during follow\u2010up. Liver histology improved in all the patients. No changes were observed in the immunological status or HIV infection. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890400206","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T22:47:15Z","timestamp":1172875635000},"page":"107-111","source":"Crossref","is-referenced-by-count":63,"title":["Treatment with recombinant \u03b1\u2010interferon of chronic hepatitis C in anti\u2010HIV\u2010positive patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Eduardo","family":"Marriott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Navas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Del","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Quiroga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Carre\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"914","article-title":"Acute and chronic hepatitis revisited. 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