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Cerebrospinal fluid (CSF) samples from all five patients contained EBV genomic sequences and EBV\u2010specific antibodies in the neurologic stage, but not during convalescence. Cerebrospinal fluid from two non\u2010neurologic IM patients had neither EBV DNA nor EBV antibodies. The EBV\u2010positive CSF of the five with neurological disorders were aseptic in culture and all negative for other human herpesvirus DNAs and antibodies: herpes simplex virus types 1 and 2, cytomegalovirus, varicella\u2010zoster virus, and human herpesvirus 6. Epstein\u2010Barr virus DNA and EBV antibodies were not detected in the CSF of 17 EBV\u2010seropositive patients with mumps meningitis, rubella encephalitis, unknown febrile convulsion, or partial epilepsy. It is suggested that EBV plays a causal role in neurologic manifestations in patients with acute and reactivated EBV infections, through direct viral invasion and immunopathological reactions. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890400405","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T22:38:43Z","timestamp":1172875123000},"page":"278-284","source":"Crossref","is-referenced-by-count":55,"title":["Epstein\u2010Barr virus genomic sequences and specific antibodies in cerebrospinal fluid in children with neurologic complications of acute and reactivated EBV 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