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One patient had low titres (1:10\u20131:80) of liver\u2010kidney microsomal (LKM\u20101) antibodies during the recovery phase and three others had transient low titres of anti\u2010smooth muscle (IgM class, 1:10) or anti\u2010ASGP\u2010R (1:150\u20131:300). Anti\u2010GOR was detected in 43 (65%) of 66 sera from 13 of these patients. There was no correlation between any of these findings and progression to chronicity. By comparison, 18 patients with AIH studied concurrently before institution of immunosuppressive therapy all had antinuclear and\/or smooth muscle antibodies, or LKM\u20101, at 1:40\u20131:640 and anti\u2010ASGP\u2010R at 1:300\u20131:2, 100. None of these 18 had evidence of HCV infection and all were seronegative for anti\u2010GOR. The findings indicate that the autoantibodies usually associated with AIH are rare in HCV infections but the virus can very occasionally induce a transient autoimmune response. Anti\u2010GOR appears to be an antibody specifically related to HCV infection and is probably not a marker of induced autoimmunity, and it does not predict progression to chronic hepatitis. \u00a9 1994 Wiiey\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890420113","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T23:19:38Z","timestamp":1172877578000},"page":"66-72","source":"Crossref","is-referenced-by-count":31,"title":["Virus\u2010induced autoimmunity in hepatitis C virus infections: A rare event"],"prefix":"10.1002","volume":"42","author":[{"given":"Barbara M.","family":"McFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Bridger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Tibbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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