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We report the case of meningora\u2010diculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)\u2010deficient, acyclovir (ACV)\u2010resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)\u20105\u2010(2\u2010bro\u2010movinyl)\u20102\u2032\u2010deoxyuridine (BVDU), 9\u2010\u03b2\u2010D\u2010ara\u2010binofuranosyladenine (vidarabine), (S)\u20101\u2010(3\u2010hy\u2010droxy \u2010 2 \u2010 phosphonylmethoxypropyl) cytosine (HPMPC), and (S)\u20109\u2010(3\u2010hydroxy\u20102\u2010phosphonyl\u2010methoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV\u2010resistant VZV infections in immunocom\u2010promised patients. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890420404","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T23:30:33Z","timestamp":1172878233000},"page":"338-347","source":"Crossref","is-referenced-by-count":43,"title":["Meningoradiculoneuritis due to acyclovir\u2010resistant varicella zoster virus in an acquired immune deficiency syndrome patient"],"prefix":"10.1002","volume":"42","author":[{"given":"R.","family":"Snoeck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"G\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sadzot\u2010Delvaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Andrei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Balzarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Reymen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ahadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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