{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:07:48Z","timestamp":1775322468021,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4146,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute aseptic meningitis (AAM) is considered as an uncommon manifestation of varicella\u2010zoster virus (VZV) recrudescence and is usually regarded as a complication of the cutaneous infection in patients with impaired cellular immunity. Indirect evidence suggests, however, that VZV\u2010associated AAM may also respond to direct spread of the virus to the leptomeninges from the cells supporting the latency. The polymerase chain reaction (PCR) was used to amplify VZV\u2010specific DNA sequences in serial cerebrospinal fluid (CSF) samples from 21 patients with AAM, who presented laboratory evidence of intrathe\u2010cal production of VZV\u2010specific antibody on follow\u2010up. Eleven of these patients never showed cutaneous zosteriform lesions. VZV\u2010DNA sequences were detected in the CSF from all patients with cutaneous zoster, as well as from six patients (55%) lacking skin lesions. Viral DNA sequences were present in six cases before the rise in specific antibody was seen in CSF, disappearing during follow\u2010up in the seven positive cases. These results support the proposed involvement of VZV in the etiology of AAM seen among normal young adults and strongly suggest that the virus can reach directly and infect the CNS from the latently infected spinal ganglia. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890430403","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:20:30Z","timestamp":1172881230000},"page":"331-335","source":"Crossref","is-referenced-by-count":111,"title":["Detection of varicella\u2010zoster virus\u2010specific DNA sequences in cerebrospinal fluid from patients with acute aseptic meningitis and no cutaneous lesions"],"prefix":"10.1002","volume":"43","author":[{"given":"Jos\u00e9 M.","family":"Echevarr\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Casas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Tenorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"de Ory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Martinez\u2010Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.10.1194"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199112000-00015"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-9-1759"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.5.959"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890270308"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.3.621"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-0786(90)90004-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198303000-00002"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1128\/jcm.29.1.76-79.1991","article-title":"Detection of varicellazoster virus (VZV) DNA in clinical samples with VZV by the polymerase chain reaction","volume":"29","author":"Kido S","year":"1991","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.5.1016"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.5.840"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890160213"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.5.578"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520390079020"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/jcm.29.7.1513-1516.1991","article-title":"Detection of varicella\u2010zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patient suffering from neurological complications associated with chickenpox or herpes zoster","volume":"29","author":"Puchhammer St\u00f3ckl E","year":"1991","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-2-221"},{"key":"e_1_2_1_18_1","first-page":"77","article-title":"Meningitis linfocitaria. 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