{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:17Z","timestamp":1785148337224,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4115,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune reactivities of blood donor sera with the peptides of various lengths (24, 30, 40 and 50 mer) and those with genotypic sequence variations in the N\u2010terminal portion of the core protein of hepatitis C virus (HCV) were compared by enzyme\u2010linked immunosorbent assays. It was found that a 40\u2010mer oligopeptide (amino acids 2\u201341) was recognized more frequently than other peptides even in serum samples that did not react with the C22\u20103 (core) by the recombinant immunoblot assay (RIBA\u2010II). On the other hand, a 30\u2010mer peptide (amino acids 1\u201330) had good correlation with viremia as confirmed by the polymerase chain reaction (PCR). In addition, four individuals showed the obvious differences in the immune responses to 30\u2010mer oligopep\u2010tides representing the 4 genotypic variations. As a result, some samples that were PCR\u2010positive but nonreactive by a commercial assay were found to react with short synthetic peptides in the N\u2010terminal portion of the core protein. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890440116","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:18:19Z","timestamp":1172881099000},"page":"88-91","source":"Crossref","is-referenced-by-count":11,"title":["Immune responses of blood donors to peptides of various lengths and those with genotypic sequence variations corresponding to the N\u2010terminal portion of the core protein of hepatitis C virus"],"prefix":"10.1002","volume":"44","author":[{"given":"Atsushi","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Sho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsunosuke","family":"Kunitomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terukatsu","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111073251901"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911303212202"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92265-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2523562"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.6.2451"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/jcm.31.1.163-164.1993","article-title":"Investigation of sera reactive to hepatitis C virus by second\u2010generation enzyme immunoassay","volume":"31","author":"Frost EH","year":"1993","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91446-H"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3647"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9524"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4486"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2496467"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5462"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150203"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-3-673"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1128\/jcm.30.8.1989-1994.1992","article-title":"Immunodominant regions within the hepatitis C virus core and putative matrix proteins","volume":"30","author":"S\u00e4llberg M","year":"1992","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1993.tb03213.x"},{"key":"e_1_2_1_18_1","first-page":"132","article-title":"Molecular cloning of the immunodominant regions of hepatitis C virus type III and IV by immunoscreening","volume":"37","author":"Sato A","year":"1993","journal-title":"Acta Virologica"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1128\/jcm.30.3.552-556.1992","article-title":"Serological markers of posttransfusion hepatitis C virus infection","volume":"30","author":"Vallari DS","year":"1992","journal-title":"Journal of Clinical Microbiology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890440116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890440116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T16:30:19Z","timestamp":1695832219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890440116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1002\/jmv.1890440116"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890440116","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}