{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:02:47Z","timestamp":1777539767751,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because 21 immunized children (13%) among the 162 confirmed Japanese encephalitis (JE) cases during 1986\u20131991 occurred in Taiwan, we collected 320 serum samples from Taiwan children aged 15\u201331 and 27\u201344 months immediately before the 1st dose (n = 41) and 1\u20133 months after the 2nd dose (n = 78, 27 pairs), and immediately before (n = 58) and 1\u20133 months after the 3rd dose (n = 143,44 pairs) to determine neutralization antibody (Nt Ab) against the Nakayama (N) and Beijing\u20101 (B) strains and two Taiwan wild type JE viruses (JEV): CC\u201027 and CH\u20101392. Our Nt results showed that (1) B vaccine stimulated a better homologous Ab response than N vaccine for Nt Ab seropositivity rate (NASR), produced a higher level of Nt titer after the primary immunization [2 doses = 100% vs. 91%, geometric mean titer (GMT) = 115 vs. 22], had a greater booster effect (3 doses: 100% vs. 95%; GMT = 320 vs. 33), and showed a better capability to neutralize two local Taiwan JEV strains, particularly only after 3 doses (ave. NASR for B vs. N = 90% vs. 10%; and GMT for B vs. N = 154 vs. 1); (2) the two wild type JEV strains had different plaque morphology and antigenic variation and the CC\u201027 strain was not neutralized as well as the CH\u20101392 strain after 3 doses of vaccine (BBB or NNN or NNB); and (3) 30% of the children had lost JEV Nt Ab one year after the 2nd dose of N vaccine and natural infection with JE virus did occur among those children after immunization. In conclusion, (1) three doses of mouse\u2010brain vaccine are the minimum requirement to protect children against the local Taiwan JEV; (2) the best strain for a JE vaccine depends on level of Nt Ab it induced, the molecular epidemiology and antigenic variation of the JEV in each local area; and (3) future vaccine must produce better B\u2010 and T\u2010cell memory. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890440204","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:14:29Z","timestamp":1172880869000},"page":"122-131","source":"Crossref","is-referenced-by-count":44,"title":["Homologous and heterologous neutralization antibody responses after immunization with Japanese encephalitis vaccine among Taiwan children"],"prefix":"10.1002","volume":"44","author":[{"given":"Chia\u2010Chi","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chwan\u2010Chuen","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huei\u2010Chu","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Yen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Yuen","family":"Yueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwong\u2010Jen J.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"187","volume-title":"Cellular and Molecular Immunology","author":"Abbas AK","year":"1991"},{"key":"e_1_2_1_3_1","unstructured":"BahnAK(1985):Description of a quantitative sample: comparison of a sample mean with an expected mean. In \u201cBasic Medical Statistics.\u201d pp127."},{"key":"e_1_2_1_4_1","first-page":"201","article-title":"Oligonucleotide fingerprint analysis of Japanses encephalitis virus strains of different geographical origin","volume":"89","author":"Banerjee K","year":"1989","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-1-37"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-71-12-2915"},{"issue":"3","key":"e_1_2_1_7_1","first-page":"21","article-title":"Comparison of plaque reduction and active mouse protection test for estimating the potency of Japanese encephalitis vaccine","volume":"19","author":"Chow FY","year":"1986","journal-title":"Chinese Journal of Microbiology and Immunology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-5250-4_22"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90004-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-39-2-203"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-43-3-534"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90052-U"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-0283-5","volume-title":"Immunologic Adjutants and Vaccines","author":"Gregoriadis G","year":"1989"},{"key":"e_1_2_1_14_1","first-page":"497","article-title":"Expression of envelope glycoprotein (E) of Japanese encephalitis virus by recombinant vaccinia virus","volume":"33","author":"Haishi S","year":"1989","journal-title":"Acta Virologica (Praha)"},{"issue":"1","key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4269\/ajtmh.1983.32.154","article-title":"Original antigenic sin in dengue","volume":"32","author":"Haistead SB","year":"1983","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809083191004"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2149\/tmh1969.10.214"},{"key":"e_1_2_1_18_1","first-page":"258","volume-title":"Immunization for Japanese Encephalitis","author":"Hsu TC","year":"1971"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60433-9"},{"key":"e_1_2_1_20_1","first-page":"313","article-title":"A field trial with an improved Japanese encephalitis vaccine in a nonendemic area of the disease","volume":"13","author":"Kanamitsu M","year":"1970","journal-title":"Biken Journal"},{"key":"e_1_2_1_21_1","first-page":"157","article-title":"Laboratory diagnosis of Japanese encephalitis comparison of the fluorescent antibody technique with virus isolation and serologic tests","volume":"11","author":"Kimoto T","year":"1968","journal-title":"Biken Journal"},{"key":"e_1_2_1_22_1","first-page":"37","article-title":"Immunogenicity of JE Nakayama and Beijing\u20101 vaccines","volume":"1","author":"Kitano T","year":"1986","journal-title":"JE & HFRS Bulletin"},{"issue":"1","key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1128\/iai.44.1.117-123.1984","article-title":"Antigenic analysis of Japanese encephalitis virus by using monoclonal antibodies","volume":"44","author":"Kobayashi Y","year":"1984","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90526-U"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90051-T"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809083191009"},{"issue":"2","key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/jcm.22.2.250-254.1985","article-title":"Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK\u201021 cells: comparison of the BHK suspension test with standard plaque reduction neutralization","volume":"22","author":"Morens DM","year":"1985","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_28_1","unstructured":"National Quarantine Service (1992): Statistics on Japanese encephalitis control in Taiwan Areaspp4."},{"key":"e_1_2_1_29_1","first-page":"579","article-title":"Vaccination with complete adjuvant\u2010added inactivated virus vaccine of Japanese encephalitis to swine for preventing viremia (with specific reference to the effects of vaccination on viremia; epidemiological study on Japanese encephalitis 35)","volume":"24","author":"Ogat M","year":"1970","journal-title":"Acta Medica Okayama"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.2.345"},{"key":"e_1_2_1_31_1","first-page":"547","article-title":"Immunotyping of different strain on Japanese encephalitis virus by antibody absorption, hemagglutination\u2010inhibition and complementfixation tests","volume":"38","author":"Okuno T","year":"1968","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken1952.28.235"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(87)90059-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1988.tb02516.x"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.878"},{"issue":"2","key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4049\/jimmunol.99.2.291","article-title":"Dengue virus identification by the plaque reduction neutralization test","volume":"99","author":"Russell PK","year":"1967","journal-title":"Journal of Immunology"},{"key":"e_1_2_1_37_1","first-page":"258","volume-title":"Immunization for Japanese Encephalitis","author":"Takaku K","year":"1971"},{"issue":"4","key":"e_1_2_1_38_1","first-page":"625","article-title":"Japanese encephalitis: current world status","volume":"63","author":"Umenai T","year":"1985","journal-title":"Bulletin World Health Organization"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036087"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.003513"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1128\/jvi.64.6.2788-2795.1990","article-title":"Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express encephalitis virus","volume":"64","author":"Yasuda A","year":"1990","journal-title":"Journal of Virology"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90827-9"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890440204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890440204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:10:35Z","timestamp":1698131435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890440204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/jmv.1890440204"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890440204","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}