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The use of a PCR\u2010based typing assay on all tissue samples, and cloned sequences from the viral coding region from each positive kidney showed that the same viral genome was present in the kidney as in the brain of the patient. Regulatory region clones all had the archetypal promoter\/enhancer structure. However, when PCR fragments from the regulatory region were digested with a restriction enzyme which cuts in region D, the region most often deleted in PML\u2010type promoters, a low level of undigested DNA remained. This DNA refractory to digestion had a rearranged sequence identical to that of the unique rearranged promoter in the brain of each patient. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890440315","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:29:49Z","timestamp":1172881789000},"page":"298-304","source":"Crossref","is-referenced-by-count":17,"title":["Brain and kidney of progressive multifocal leukoencephalopathy patients contain identical rearrangements of the JC virus promoter\/enhancer"],"prefix":"10.1002","volume":"44","author":[{"given":"Grace S.","family":"Ault","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald 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