{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:39:06Z","timestamp":1788489546142,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4024,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relatedness of enteroviral isolates associated with two recent outbreaks in Canada was assessed using direct sequencing of amplicons derived from a large portion of the 5\u2032 nontrans\u2010lated region (NTR) of the viral genome. The amplicons of 60 echovirus 30 isolates originating from seven different provinces in 1991 were found to share 99% or greater sequence identity. Recent coxsackievirus B1 isolates characterised in the same manner were identical to each other. When the 5\u2032 NTR sequence of these isolates was compared to prototype strains a difference of 11\u201315% in nucleotide composition was observed. These results indicate that the variability of nucleotide sequence found in 5\u2032 NTRs can be utilized to identify rapidly enteroviral strains associated with particular outbreaks and distinguish them from other strains and serotypes. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890440406","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:27:44Z","timestamp":1172881664000},"page":"340-347","source":"Crossref","is-referenced-by-count":33,"title":["Molecular epidemiology of enterovirus outbreaks in Canada during 1991\u20131992: Identification of echovirus 30 and coxsackievirus B1 strains by amplicon sequencing"],"prefix":"10.1002","volume":"44","author":[{"given":"Michael A.","family":"Drebot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Y.","family":"Nguan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice J.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer H. 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