{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:13:18Z","timestamp":1759335198005},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":4024,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are about 20 types of human papillomavi\u2010ruses (HPVs) which are generally believed to be confined to the anogenital tract. HPV 16 is the most common of these. Four squamous cell carcinomas of the finger from three individuals were analyzed for the presence of HPV DNA by <jats:italic>Pst<\/jats:italic> 1 restriction enzyme digest and Southern blotting. Under high stringency conditions, all were positive for HPV 16. The DNA from each patient was digested with a panel of restriction enzymes so that integration of HPV into the genome could be evaluated. Three of three samples contained high molecular weight oligomeric circular DNA arranged as catanates. None showed integration. To determine if the HPV was transcriptionally active, RNA was isolated, reverse transcribed, and amplified using primers that amplified the unspliced E6 transcript and the E6I and E6II spliced transcripts. All of the patient biopsies assayed expressed the unspliced E6 transcript and the spliced E6I transcript with the E6I transcript being the most abundant. The E6II transcript was not detected in any of the samples. These findings indicate that HPV plays a role in the development of squamous cell carcinoma of the finger and the role of the malignant genital HPV needs to be carefully looked at in areas outside the genital region. It also suggests that the natural history of HPV in areas outside the cervix may not be identical to that of HPV in the anogenital region. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890440410","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:27:44Z","timestamp":1172881664000},"page":"369-378","source":"Crossref","is-referenced-by-count":19,"title":["Possible role for human papillomavirus 16 in squamous cell carcinoma of the finger"],"prefix":"10.1002","volume":"44","author":[{"given":"Mary","family":"S\u00e1nchez\u2010Lanier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charla","family":"Triplett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Campion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90086-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90027-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1001\/archderm.1991.04520010059008","article-title":"Detection of human papillomavirus DNA in squamous cell carcinoma of the nail bed and finger determined by polymerase chain reaction","volume":"127","author":"Ashinoff R","year":"1991","journal-title":"Archives of Dermatology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1128\/jvi.61.4.962-971.1987","article-title":"Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines","volume":"61","author":"Baker CC","year":"1987","journal-title":"Journal of Virology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520202"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198901000-00011"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/jvi.65.2.606-612.1991","article-title":"Analysis of the physical state of different human papillomavirus DNAs in intraep\u2010ithelial and invasive cervical neoplasm","volume":"65","author":"Cullen AP","year":"1991","journal-title":"Journal of Virology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890360402"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1128\/jvi.63.11.4898-4903.1989","article-title":"Heterogeneity of the human papillomavirus group","volume":"63","author":"de Villiers EM","year":"1989","journal-title":"Journal of Virology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2537532"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(87)90478-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410109"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90545-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1002\/j.1460-2075.1989.tb08570.x","article-title":"HPV E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes","volume":"8","author":"Hawley\u2010Nelson P","year":"1989","journal-title":"The EMBO Journal"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1128\/jvi.64.2.519-526.1990","article-title":"Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18","volume":"64","author":"Hudson JB","year":"1990","journal-title":"Journal of Virology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-5-1261"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-11-3099"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190531"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420180093037"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/jvi.63.10.4417-4421.1989","article-title":"The E6 and the E7 genes are necessary and sufficient for transformation of primary human keratinocytes","volume":"63","author":"M\u00fcnger K","year":"1989","journal-title":"Journal of Virology"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/archderm.1987.01660350111025","article-title":"Epidermodysplasia verruciformis. 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