{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:24:55Z","timestamp":1766690695837},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":3934,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of \u03b1\u2010interferon on the hepatitis C genotypes was examined in 25 anti\u2010HCV\u2010positive hemophilic patients. The rate of multiple HCV genotypes in patients who are likely to have mixed infections was also studied. Pretreatment results showed that 3\/25 (12%) patients had a change in genotypes, whereas posttreatment this rose to 10\/25 (40%). Seven of 10 (70%) patients who showed a change in genotype had a clinical response to \u03b1\u2010interferon. Six of 25 (24%) patients showed a complete clinical response to \u03b1\u2010interferon, and the majority of these were either type 2 or 3. This study supports previous evidence that type 1 is less likely to respond to \u03b1\u2010interferon, and that a\u2010interferon may alter the concentrations of the various circulating genotypes present in multiply\u2010infected patients. There are many difficulties in studying hepatitis C in hemophilic patients due to the sequence heterogeneity within each individual, and this study has shown that no ideal method exists as yet for looking at HCV genotypes in multiply\u2010infected individuals. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890450308","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:37:31Z","timestamp":1172882251000},"page":"284-287","source":"Crossref","is-referenced-by-count":16,"title":["Hepatitis C genotypes in hemophilic patients treated with alpha\u2010interferon"],"prefix":"10.1002","volume":"45","author":[{"given":"Helen","family":"Devereux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Telfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Dusheiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.11.4942"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/jcm.29.11.2528-2534.1991","article-title":"Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma","volume":"29","author":"Cha TA","year":"1991","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.7144"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-5-1131"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401133300215"},{"key":"e_1_2_1_7_1","first-page":"61","article-title":"Drugs and Therapeutics Bulletin","volume":"2","year":"1993","journal-title":"Managing patients with hepatitis C."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190104"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140227"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91124-S"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33193142314.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91648-A"},{"key":"e_1_2_1_13_1","first-page":"215","article-title":"Detection of the hepatitis C virus RNA by a two\u2010stage polymerase chain reaction with two pairs of primers deduced from the 5\u2032 non\u2010coding region","volume":"60","author":"Okamoto H","year":"1990","journal-title":"Japanese Journal of Experimental Medicine"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-3-673"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90762-E"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-11-2385"},{"key":"e_1_2_1_17_1","unstructured":"PrestonFE MakrisM JarvisL SimmondsP(1994): Hepatitis C subtypes in haemophilia; serotype and genotype detection and their clinical correlation. International Congress of the World Federation of Haemophilia (abstract no. 133)."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1128\/jcm.31.6.1493-1503.1993","article-title":"Mapping of serotypespecific, immunodominant epitopes to the NS\u20104 region of hepatitis C virus (HCV):\nuse of type\u2010specific peptides to serologically differentiate infection with HCV types 1, 2 and 3","volume":"31","author":"Simmonds P","year":"1993","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-4-661"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80205-3"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1128\/jvi.65.3.1105-1113.1991","article-title":"Structure and organisation of the hepatitis C virus genome isolated from human carriers","volume":"65","author":"Takamizawa A","year":"1991","journal-title":"Journal of Virology"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08312.x"},{"key":"e_1_2_1_23_1","first-page":"187","article-title":"Alpha interferon for hepatitis C infection in haemophilic patients","volume":"87","author":"Telfer PT","year":"1994","journal-title":"British Journal of Haematology [Supplement]"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890450308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890450308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:32:30Z","timestamp":1698348750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890450308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/jmv.1890450308"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890450308","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}