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To determine the origin and genetic diversity of HTLV\u2010I in this group, 1,039 bp spanning selected regions of the HTLV\u2010I <jats:italic>gag, pol, env<\/jats:italic> and <jats:italic>pX<\/jats:italic> genes were enzymatically amplified and sequenced directly from DMA of five Mashhadi Jews (three with spastic myelopathy and two asymptomatic carriers). Alignment and comparison of these sequences with cosmopolitan and Australo\u2010Melanesian topotypes of HTLV\u2010I indicated that the HTLV\u2010I strains from Mashhadi Jews, which were \u2a7e99.9% identical among themselves, exhibited considerable sequence similarity (\u2a7e99%) to HTLV\u2010I strains from southern India, suggesting a common source of infection. Phylogenetic analysis, using the maximum parsimony method, was consistent with a single\u2010source introduction of HTLV\u2010I into the Mashhadi Jewish community. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890450402","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:35:58Z","timestamp":1172882158000},"page":"361-366","source":"Crossref","is-referenced-by-count":12,"title":["Human T\u2010cell lymphotropic virus type I in Iranian\u2010born Mashhadi Jews: Genetic and phylogenetic evidence for common source of infection"],"prefix":"10.1002","volume":"45","author":[{"given":"V. R.","family":"Nerurkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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