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The sensitivity of the technique made it possible to detect as few as 5\u201310 target molecules in 15 \u03bcl of saliva. HHV\u20106 was present in 63% of salivary gland biopsies and in 3% of salivas from healthy persons. No significant difference in the presence of HHV\u20106 was detected in specimens from donors with common cold, RAU, or HIV\u2010infected patients. HHV\u20107 was present in 75% of salivary glands and in 55% of salivas from healthy persons. HHV\u20107 was detected with similar frequency in salivas from donors with common cold or RAU. Salivas from HIV\u2010infected patients harbored HHV\u20107 with higher frequency (81%) and increased viral load. These results show that salivary glands are a site of persistent infection for both HHV\u20106 and HHV\u20107. However, the two viruses seem to differ in their biological properties: (1) HHV\u20106 is rarely present in saliva in detectable amounts, while HHV\u20107 is frequently detected; and (2) immunosuppression by acquired immunodeficiency syndrome (AIDS) increases the frequency of detection and the viral load of HHV\u20107, but does not have a significant effect on HHV\u20106 shedding in saliva. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890450418","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:35:58Z","timestamp":1172882158000},"page":"462-468","source":"Crossref","is-referenced-by-count":86,"title":["Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals"],"prefix":"10.1002","volume":"45","author":[{"given":"D.","family":"Di 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