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IgM and IgG containing CIC were studied using both Clq and conglutinin (K) in an immunoglobulin\u2010specific solid\u2010phase enzyme immunoassay. CIC were a common feature of chronic hepatitis C with 96.3% of patients with at least one abnormal test result. The prevalence of elevated IgG\u2010K, IgM\u2010K, IgG\u2010C1q, and IgM\u2010C1q CIC was 70.3%, 50.0%, 64.8%, and 35.1%, respectively. The prevalence of IgG class CIC was higher than IgM class CIC (<jats:italic>P<\/jats:italic> = 0.038 for K\u2010CIC and <jats:italic>P<\/jats:italic> = 0.01 for C1q\u2010CIC, respectively). There is correlation between IgG\u2010K CIC and IgG\u2010C1q CIC (r = 0.445, <jats:italic>P<\/jats:italic>= 0.0021, IgG\u2010K CIC and ISM\u2010Clq CIC (r = 0.348, <jats:italic>P<\/jats:italic> = 0.020). IgM\u2010K CIC and aspartic arninotransferase (r = 0.321, <jats:italic>P<\/jats:italic>= 0.015). IgM\u2010K CIC and alanine aminotransferase (r =0.301, <jats:italic>P<\/jats:italic> = 0.027). Compared to patients with chronic persistent hepatitis and chronic lobular hepatitis, patients with chronic active hepatitis have a higher prevalence of elevated IgG\u2010K CIC (77.2% vs. 40.0%, <jats:italic>P<\/jats:italic> = 0.029) and IgM\u2010K CIC (56.8% vs. 20.0%, <jats:italic>P<\/jats:italic> = 0.038). The concentration of IgG\u2010K, IgM\u2010K, and IgM\u2010C1q CIC in the former was significantly higher than that in the latter, respectively. In conclusion, IgG class CIC is the major type of CIC in chronic hepatitis C. Conglutinin\u2010binding CIC correlates with more severe tissue damage. CIC may play a role in the pathogenesis of chronic hepatitis C. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890460104","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T01:00:35Z","timestamp":1172883635000},"page":"12-17","source":"Crossref","is-referenced-by-count":17,"title":["Circulating immune complexes in chronic hepatitis C"],"prefix":"10.1002","volume":"46","author":[{"given":"Jung\u2010Fa","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Eing","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Shang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu\u2010Yau","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juei\u2010Hsiung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"292","article-title":"Non\u2010specificity of circulating immune complexes in patients with acute and chronic liver disease","volume":"40","author":"Abrass CK","year":"1980","journal-title":"Clinical Experimental Immunology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150604"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90210-8"},{"key":"e_1_2_1_5_1","first-page":"673","article-title":"Chronic liver disease: The detection and characterization of circulating immune complexes","volume":"49","author":"Brown SE","year":"1983","journal-title":"Immunology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02592281"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(80)90046-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92828-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(82)90254-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130603"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890390412"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1128\/jvi.67.4.1953-1958.1993","article-title":"Equilibrium centrifugation studies of hepatitis C virus: Evidence for circulating immune complexes","volume":"67","author":"Hijikata M","year":"1993","journal-title":"Journal of Virology"},{"key":"e_1_2_1_13_1","first-page":"914","article-title":"Acute and chronic hepatitis, revisited","author":"International group","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4049\/jimmunol.99.1.82","article-title":"Biological activities of r\u2010globulin. 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