{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:05:41Z","timestamp":1744149941141},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":3842,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Israel is endemic for hepatitis E virus (HEV), the causative agent of enteric non\u2010A, non\u2010B hepatitis. Transmission is via the feco\u2010oral route but the possibility of transmission through blood transfusion has been raised. This question was addressed by examining sera from 188 hemophilic patients in Israel. screening was performed with an enzyme immunoassay (EIA) for antibody against hepatitis E virus (anti\u2010HEV) and confirmed with a neutralization test. Sixteen patients (9%) were seropositive for anti\u2010HEV. A statistically significant difference was not found between the seroprevalence in this group and that of a healthy Israeli control population, matched for sex and age. The anti\u2010HEV\u2010seropositive hemophiliacs had the same seroprevalence of antibodies to hepatitis B and C virus and to HIV and the same number of cases with chronic hepatitis as among the anti\u2010HEV\u2010seronegative patients. The seroprevalence of antibodies to hepatitis A virus (anti\u2010HAV) was, on the other hand, higher in the anti\u2010HEV\u2010seropositive group. This study indicates that HEV is not transmitted by cryopre\u2010cipitate or lyophilized factor concentrates. High prevalence of coinfection with hepatitis A supports our conclusion that HEV infection in Israeli hemophiliacs was due mainly to feco\u2010oral transmission. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890460213","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:55:47Z","timestamp":1172883347000},"page":"153-156","source":"Crossref","is-referenced-by-count":23,"title":["Hepatitis E virus infection in hemophiliacs"],"prefix":"10.1002","volume":"46","author":[{"given":"Asher","family":"Barzilai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuory V.","family":"Karetnyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael O.","family":"Favorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Mendelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peretz","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A.","family":"Fields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Varon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Martinowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548709117194"},{"key":"e_1_2_1_3_1","first-page":"23","article-title":"Evidence for a virus in non\u2010A, non\u2010B hepatitis transmitted via the fecal\u2010oral route","volume":"20","author":"Balayan MS","year":"1983","journal-title":"Inter\u2010 virology"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91674-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890340407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91647-Q"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.6.1001"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890450314"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1128\/jvi.68.11.7067-7074.1994","article-title":"Artificial mosaic protein containing antigenic epitopes of hepatitis E virus","volume":"68","author":"Khudyakov YE","year":"1994","journal-title":"Journal of Virology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91548-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2107574"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02774990"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90598-B"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890460213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890460213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T03:15:01Z","timestamp":1698376501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890460213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/jmv.1890460213"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890460213","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}