{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:04:19Z","timestamp":1775207059432,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":3781,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genomes of 477 Japanese strains of molluscum contagiosum virus (MCV) were analyzed using an in\u2010gel digestion method with the restriction enzyme <jats:italic>Bam<\/jats:italic>HI, and classified into four types, including a newly detected type (MCV type 4). All type 1 (MCV\u20101) genomes examined so far in Japan showed a common difference from the genome of the MCV\u20101 prototype (MCV\u2010l p), the type reported to be most prevalent in Europe. The common markers of the variants of MCV\u20101 were 24\u2010kbp fusion fragments generated by the loss of a <jats:italic>Bam<\/jats:italic>Hl site between the D2 and F fragments of MCV\u20101 p. These variants of MCV\u20101 were classified into three groups (MCV\u2010lva, MCV\u20101vb, MCV\u2010l vc), with the variability among them being due to additions and losses of <jats:italic>Bam<\/jats:italic>Hl sites located in the right terminus and around the Eand I fragments of MCV\u2010lva. The restriction map of MCVB was generated and lined up with those of the other types. Cross\u2010hybridization analysis revealed that the organization of all types of MCV genomes were essentially colinear. Considerable numbers of <jats:italic>Bam<\/jats:italic>Hl restriction sites were conserved between MCV\u20102 and 4, indicating a close analogy between them. The overall prevalence of MCV, as shown by the ratios of MCV\u20101 (MCV\u20101p):MCV\u20102:MCV\u20103:MCV\u20104, was 436(0):13: 24:4. Thus, the molecular epidemiology of MCV in Japan is characterized by the absence of the European prototype of MCV\u20101, the exclusive occurrence and abundance of variants of MCV\u20101, a greater prevalence of MCV\u20103 over MCV\u20102, and the presence of MCV\u20104. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890460409","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T02:42:06Z","timestamp":1172889726000},"page":"339-348","source":"Crossref","is-referenced-by-count":34,"title":["Analysis of molluscum contagiosum virus genomes isolated in Japan"],"prefix":"10.1002","volume":"46","author":[{"given":"J.","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Muraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890330313"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00125128"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1050"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3952500"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890180105"},{"key":"e_1_2_1_7_1","first-page":"2113","volume-title":"Fields Virology","author":"Fenner F","year":"1990"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb05801.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.7.834b"},{"key":"e_1_2_1_10_1","first-page":"2079","volume-title":"Fields Virology","author":"Moss B","year":"1990"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309652"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(77)90141-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-3-673"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890380102"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb07763.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800068072"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1970.10667262"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90048-4"},{"key":"e_1_2_1_19_1","volume-title":"Molecular cloning","author":"Sambrook J","year":"1989"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.4.898"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890270203"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890320102"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890460409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890460409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T22:22:43Z","timestamp":1698272563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890460409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,8]]}},"alternative-id":["10.1002\/jmv.1890460409"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890460409","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8]]}}}