{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:41:24Z","timestamp":1789879284068,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":3781,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1995,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development over time of antibodies to human papillomavirus type 6 (HPV 6) was studied prospectively in a group of 26 condyloma patients receiving multiple treatments, as well as in 17 healthy subjects with a new HPV 6 infection. The condyloma patients provided serum samples during 2\u201312 visits over a period of 1\u201320 months, and the levels of IgA, IgG and IgM antibodies to HPV 6, 11 and 16 capsids, and to HPV 6\u2010derived peptide antigens were determined. Among the capsid antibodies, the IgG and IgA responses against HPV 6 were the most prominent, whereas IgM was detected only in a few patients. During follow\u2010up, seroconversion to HPV capsids was found in six patients and antibody peaks disappeared during follow\u2010up in nine patients. There was no association between serology and cure of the wart.<\/jats:p><jats:p>One hundred twenty subjects who reported multiple sexual partners, but found negative for HPV DNA at multiple anogenital and oral sites, provided serum samples and swabs for HPV DNA analysis at 2\u20137 visits during 4\u201374 months. Seventeen subjects acquired HPV 6 DNA and were included in the study. Serum IgA, IgG and IgM antibodies to HPV 6 capsids were induced concomitantly with the acquisition of viral DNA (<jats:italic>P<\/jats:italic> = 0.02, 0.002 and 0.006, respectively), and declined again when the viral DNA was no longer detectable.<\/jats:p><jats:p>In conclusion, antibodies to HPV 6 did not predict the clinical course of condylomatous disease, but appear to be useful mainly as epidemiological markers of viral exposure. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1890460413","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T02:42:06Z","timestamp":1172889726000},"page":"368-374","source":"Crossref","is-referenced-by-count":19,"title":["Prospective study on the development of antibodies against human papillomavirus type 6 among patients with condyloma acuminata or new asymptomatic infection"],"prefix":"10.1002","volume":"46","author":[{"given":"A.","family":"Wikstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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V.","family":"Quint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dillner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890390414"},{"key":"e_1_2_1_3_1","first-page":"703","article-title":"Human papillomavirus detection in paraffin embedded cervical carcinoma and metastases of the carcinomas by the polymerase chain reaction","volume":"135","author":"Claas ECJ","year":"1989","journal-title":"American Journal of Pathology"},{"key":"e_1_2_1_4_1","first-page":"50","article-title":"Laboratory techniques in the investigation of human papillomavirus infection","volume":"68","author":"de Villiers EM","year":"1992","journal-title":"Genitourinary Medicine"},{"key":"e_1_2_1_5_1","first-page":"35","article-title":"Antibody responses to defined HPV epitopes in cervical neoplasia","volume":"5","author":"Dillner J","year":"1994","journal-title":"Papillomavirus Report"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3838"},{"key":"e_1_2_1_7_1","first-page":"134","article-title":"A population\u2010based seroepidemio logical study of cervical cancer","volume":"54","author":"Dillner J","year":"1994","journal-title":"Cancer Research"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530306"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","unstructured":"HeinoP EklundC Fredriksson\u2010ShanazarianV GoldmanS SchillerJT DillnerJ(1995):Serum IgG antibodies against human papillomavirus type 16 capsids associate with anal epidermoid carcinoma. 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