{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:57:51Z","timestamp":1791179871342,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,1,9]],"date-time":"2004-01-09T00:00:00Z","timestamp":1073606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 1,000 million infections with dengue viruses are estimated to occur annually. The majority of the cases develop mild disease, whereas only small proportion of the infected individuals develop severe hemorrhagic manifestations at the end of the acute phase of illness. In this study, the value of plasma levels of vascular cell adhesion molecule 1 (VCAM\u20101) in the pathogenesis and prognosis of dengue illness was investigated in children with dengue infections of varying severity. The plasma levels of soluble VCAM\u20101 (sVCAM\u20101) were measured in serial plasma samples obtained from 168 children aged between 7 months and 14 years with confirmed dengue infection. Of those children, 71 were suffering from dengue fever, 30 were suffering from dengue hemorrhagic fever, and 67 were suffering from dengue shock syndrome. Plasma samples obtained from 21 patients with febrile illness other than dengue served as controls. A commercially available kit (R&amp;D Systems, Oxon, UK) was used to measure the levels of sVCAM\u20101 in plasma samples. sVCAM\u20101 was elevated during acute dengue infection, and significantly elevated among dengue shock syndrome patients as compared to dengue fever or dengue hemorrhagic fever patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Statistical analysis revealed that sVCAM\u20101 was associated with dengue disease severity and the time post infection (acute vs. convalescent phase) and not with age, sex, or previous exposure of the patients to dengue infection. A significant difference was found in the plasma levels of sVCAM\u20101 between dengue shock syndrome and dengue fever patients, however, the prognostic value of this marker in the acute stage of dengue illness proved to be limited. These data also favor to study the further elucidation of the role of sVCAM\u20101 in the pathogenesis of dengue infections. J. Med. Virol. 72:445\u2013450, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20007","type":"journal-article","created":{"date-parts":[[2004,1,23]],"date-time":"2004-01-23T12:02:29Z","timestamp":1074859349000},"page":"445-450","source":"Crossref","is-referenced-by-count":58,"title":["Elevation of soluble VCAM\u20101 plasma levels in children with acute dengue virus infection of varying severity"],"prefix":"10.1002","volume":"72","author":[{"given":"Penelopie","family":"Koraka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Murgue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Deparis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.M.","family":"van Gorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatty E.","family":"Setiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.M.E.","family":"Osterhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4226-4232.1997"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.20.3.776-781.1978"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2000.tb01474.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90661-W"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655401750173968"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.412"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/314680"},{"issue":"6","key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1128\/CDLI.7.6.867-871.2000","article-title":"Evaluation of six immunoassays for detection of dengue virus\u2010specific immunoglobulin M and G antibodies","volume":"7","author":"Groen J","year":"2000","journal-title":"Clin Diagn Lad Immunol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02288-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3277268"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.63.71"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655401300077342"},{"key":"e_1_2_1_14_1","first-page":"273","volume-title":"Dengue and dengue haemorrhagic fever","author":"Kurane I","year":"1997"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.324"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2007"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049733"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200207)32:7<1821::AID-IMMU1821>3.0.CO;2-A"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004360000298"},{"key":"e_1_2_1_20_1","first-page":"385","article-title":"Vascular and nonvascular expression of INCAM\u2010110. 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