{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T10:43:26Z","timestamp":1787481806308,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,2,13]],"date-time":"2004-02-13T00:00:00Z","timestamp":1076630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human herpesvirus\u20108 (HHV\u20108) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV\u2010infected and uninfected patients. HHV\u20108 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV\u20108 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV\u20108 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92\/2,470; 95% CI 2.9\u20134.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and C\u00f3rdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) between men and women or age related, except in Brazil where positive cases were 30\u201349\u2010year\u2010old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low\u2010prevalence regions. South America is a large sub\u2010continent with a wide spectrum of population and geographical characteristics, thus, more HHV\u20108 prevalence studies should be necessary to establish possible regional differences. J. Med. Virol. 72:661\u2013667, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20029","type":"journal-article","created":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T10:00:24Z","timestamp":1077184824000},"page":"661-667","source":"Crossref","is-referenced-by-count":31,"title":["Seroprevalence of human herpesvirus\u20108 in blood donors from different geographical regions of Argentina, Brazil, and 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