{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:57Z","timestamp":1791330297995,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treating acute hepatitis C with interferon alpha prevents chronicity in nearly all cases when therapy is initiated within 3 months after infection. However, 15\u201350% of untreated patients may clear the hepatitis C virus (HCV) spontaneously. Therefore, factors are needed to identify patients prior to therapy who have a higher or lower risk for developing a chronic course to avoid unnecessary treatment. The role of the HCV genotype for spontaneous recovery from acute hepatitis C has been discussed controversially. In the year 2002, all 1,176 new incoming prisoners in a Northern German prison for young men (age 16\u201324) were screened for anti\u2010HCV antibodies and 92 tested positive. Ninety eight percent of these reported i.v.\u2010drug abuse for a median of 32 months prior to imprisonment. HCV\u2010RNA negative individuals (21%) were serotyped and HCV\u2010RNA positive patients were genotyped. The prevalence of HCV genotype 3 was significantly higher among individuals who had cleared HCV spontaneously as compared to chronically infected patients (86% vs. 38%; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Ninety three percent of individuals exposed to HCV genotype 1 but only 63% of individuals exposed to genotype 3 experienced a chronic course of the infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.006). Thus, acute infection in young Caucasian men with HCV genotype 3 leads more often to spontaneous clearance than infection with HCV genotype\u20101. Considering also the high chance of successful treatment of chronic HCV genotype 3 infection with pegylated\u2010interferon in combination with ribavirin, we suggest not to treat acute hepatitis C genotype 3 infection early but rather to wait at least 3 months after the onset of symptoms when chronicity becomes likely. J. Med. Virol. 73:387\u2013391, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20103","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T16:01:53Z","timestamp":1085414513000},"page":"387-391","source":"Crossref","is-referenced-by-count":86,"title":["High rate of spontaneous clearance of acute hepatitis C virus genotype 3 infection"],"prefix":"10.1002","volume":"73","author":[{"given":"Marc","family":"Lehmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela F.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masyar","family":"Monazahian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Tillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36808"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80411-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11901-003-0011-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4220"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020047"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00668-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50019"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360704"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011232"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26511"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00354-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06102-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510380302"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200002)60:2<122::AID-JMV3>3.0.CO;2-#"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.19288"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36380"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010398"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199911270-00013"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.17.s3.26.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20221"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.20103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.20103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T01:44:38Z","timestamp":1700271878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.20103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,24]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/jmv.20103"],"URL":"https:\/\/doi.org\/10.1002\/jmv.20103","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,24]]}}}