{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:30:09Z","timestamp":1790267409647,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T00:00:00Z","timestamp":1095120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>West Nile (WN) virus is a mosquito\u2010borne flavivirus that can cause lethal encephalitis in humans and horses. The WN virus endemic in New York City (NY) in 1999 caused large\u2010scale mortality of wild birds that was not evident in endemic areas in other parts of the world, and the pathogenesis of the WN virus strain isolated in NY (NY strain) appears to differ from that of previously isolated strains. However, the pathogenesis of NY strain infection remains unclear. This study examined CC (RANTES\/CCL5, MIP\u20101\u03b1\/CCL3, MIP\u20101\u03b2\/CCL4) and CXC (IP\u201010\/CXCL10, B lymphocyte chemoattractant (BLC\/CXCL13), and B cell\u2010 and monocyte\u2010activating chemokine (BMAC\/CXCL14)) chemokine expression during lethal NY strain and non\u2010lethal Eg101 strain infection in mice. We found that the mRNA of the CC chemokines, RANTES, MIP\u20101\u03b1, MIP\u20101\u03b2, and IP\u201010 was highly up\u2010regulated in the brain of NY strain\u2010infected mice. By contrast, BLC mRNA was not detected in either group of mice, and BMAC mRNA was highly up\u2010regulated in late stage of infection with the non\u2010lethal Eg101 strain relative to levels in NY strain\u2010infected mice. J. Med. Virol. 74:507\u2013513, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20205","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T16:03:38Z","timestamp":1095177818000},"page":"507-513","source":"Crossref","is-referenced-by-count":65,"title":["Different chemokine expression in lethal and non\u2010lethal murine west nile virus infection"],"prefix":"10.1002","volume":"74","author":[{"given":"Kazuya","family":"Shirato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kariwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241472398"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.10.7832-7840.1997"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1372"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01718310"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7667639"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.6.1939"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.4.2578-2586.2003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031223"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.3.246"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01374-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0704.010410"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35876"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/oxfordjournals.aje.a120531","article-title":"Antigenic variation of West Nile virusin relation to geography","volume":"82","author":"Hamman MH","year":"1965","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0505.990506"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05384-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323930"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01636.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.4049\/jimmunol.141.10.3606","article-title":"Protection of mice against Japanese encephalitis virus by passive administration with monoclonal antibodies","volume":"141","author":"Kimura\u2010Kuroda J","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.16.8408-8419.2002"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.855"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5448.2333"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.4049\/jimmunol.160.2.970","article-title":"Dynamic regulation of alpha\u2010 and beta\u2010chemokine expression in the central nervous system during mouse hepatitis virus\u2010induced demyelinating disease","volume":"160","author":"Lane TE","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.3.1415-1424.2000"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2327"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.7.4091"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.963"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb02704.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.19.9267-9280.2000"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(91)90013-4"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/347669a0"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1821"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2003.tb03381.x"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"11173","DOI":"10.1128\/JVI.74.23.11173-11180.2000","article-title":"DNA vaccines encoding interleukin\u20108 and RANTES enhance antigen\u2010specific Th1\u2010type CD4(+) T\u2010cell mediated protective immunity against herpes simplex virus type 2 in vivo","volume":"74","author":"Sin J","year":"2000","journal-title":"J Virol"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.5.677"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7682337"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms982oa"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2524"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400042339"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.20205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.20205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:11:28Z","timestamp":1700266288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.20205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,14]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/jmv.20205"],"URL":"https:\/\/doi.org\/10.1002\/jmv.20205","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,14]]}}}