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This study determined virus prevalence estimates and the risk factors associated with HHV\u20108 infection. Cross\u2010sectional, enrollment visit data were analyzed from a prospective cohort study of perinatal transmission of HHV\u20108 in Lusaka, Zambia. Exposure data were obtained via structured interview, physical examination, medical chart review, and laboratory testing. Among 3,160 antenatal women serologically screened for HHV\u20108 between September 1998 and October 2000, 40.2% were seropositive. The HHV\u20108 positive women were more likely to be co\u2010infected with HIV\u20101 than those who were HHV\u20108 negative (34% vs. 26%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Of 154 variables evaluated by logistic regression analyses, only three risk factors, have emerged as independent predictors of HHV\u20108 positive serology: diagnosis of genital warts, HIV\u20101 co\u2010infection and primary education. The association of HHV\u20108 infection with genital warts and HIV\u20101 co\u2010infection suggests heterosexual transmission of HHV\u20108. HIV\u20101 infection may also act as a marker for particular behaviors, which could be sexual in nature, that are associated with both HIV\u20101 and HHV\u20108 transmission. Since HHV\u20108 facilitates development of AIDS\u2010related Kaposi's sarcoma (KS), the results of this study could be utilized to identify specific population groups of pregnant women who are at increased risk for this disease. J. Med. Virol. 75:93\u2013100, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20242","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T22:51:43Z","timestamp":1100299903000},"page":"93-100","source":"Crossref","is-referenced-by-count":38,"title":["Epidemiological characteristics of human herpesvirus\u20108 infection in a large population of antenatal women in 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