{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:11:44Z","timestamp":1789384304569,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T00:00:00Z","timestamp":1100217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated the overall impact of human metapneumovirus (hMPV) infection in 1,505 children and their households, and compared it with infections due to respiratory syncytial virus (RSV) and influenza viruses. Nasopharyngeal swabs were used at enrollment to collect specimens for the detection of hMPV, RSV, and influenza virus RNA by reverse\u2010transcriptase polymerase chain reaction (RT\u2010PCR). hMPV was detected in 42 children (2.8%), RSV in 143 (9.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 vs. hMPV), and influenza viruses in 230 (15.3%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 vs. hMPV). Of the 42 hMPV\u2010positive samples, one was also positive for RSV and six for influenza viruses, for a co\u2010infection rate of 16.7%. Clinically, hMPV was identified only in patients with acute respiratory infection, whereas RSV and influenza viruses were also detected in patients with different clinical manifestations. Symptoms with statistically significant different proportions at presentation were fever (more frequent in the hMPV\u2010 and influenza\u2010positive children) and wheezing with bronchiolitis or asthma exacerbation (more frequent among hMPV\u2010 and RSV\u2010positive cases). The households of the hMPV\u2010 and the influenza\u2010positive children had significantly more illnesses, needed significantly more medical visits, received more antipyretics, and missed significantly more work or school days than those of the RSV\u2010positive children. Results show that hMPV is an emerging cause of acute respiratory infection in childhood, and may have a significant clinical and socioeconomic impact on children and their families. J. Med. Virol. 75:101\u2013104, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20243","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T22:50:35Z","timestamp":1100299835000},"page":"101-104","source":"Crossref","is-referenced-by-count":127,"title":["Impact of human metapneumovirus in childhood: Comparison with respiratory syncytial virus and influenza viruses"],"prefix":"10.1002","volume":"75","author":[{"given":"Samantha","family":"Bosis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert G.M.","family":"Niesters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Crovari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.M.E.","family":"Osterhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Principi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,12]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Textbook of pediatrics","author":"Behrman RE","year":"2004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.030017"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000126401.21779.74"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10391"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10572"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/382536"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000105103.60288.0e"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.5.535"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0906.030009"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000092188.48726.e4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)00926-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/89098"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/379200"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000108190.09824.e8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025472"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06528-X"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.20243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.20243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:19:53Z","timestamp":1700198393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.20243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,12]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/jmv.20243"],"URL":"https:\/\/doi.org\/10.1002\/jmv.20243","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,12]]}}}