{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:24:27Z","timestamp":1761596667855},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,8,14]],"date-time":"2001-08-14T00:00:00Z","timestamp":997747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue virus (DV) infection can result in either a mild febrile illness known as dengue fever (DF) or a life\u2010threatening disease called dengue hemorrhagic fever (DHF). DHF is more prevalent in patients undergoing secondary DV infection. This observation has led to the hypothesis that DHF may be the result of immune reactions to the secondary DV infection; an event termed immunopathology. Two cellular factors, MIP\u20101\u03b1 and MIP\u20101\u03b2, have been found to be induced by infection with DV. MIP\u20101 induction by DV infection was observed in a myelomonocytic cell line, as well as in peripheral blood mononuclear cells isolated from a dengue naive donor. MIP\u20101 induction was not due to factors secreted by infected cells. In fact, replication\u2010competent virus was required to induce MIP\u20101. Evidence is also provided that MIP\u20101 genes are expressed in patients with dengue disease. It is hypothesized that these chemokines may have roles in the immunopathology of dengue infections and may contribute to fever and bone marrow suppression observed in patients with DV infections. J. Med. Virol. 65:324\u2013330, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.2037","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:55:21Z","timestamp":1030305321000},"page":"324-330","source":"Crossref","is-referenced-by-count":37,"title":["MIP\u20101\u03b1 and MIP\u20101\u03b2 induction by dengue virus"],"prefix":"10.1002","volume":"65","author":[{"given":"Tammy A.","family":"Spain\u2010Santana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Marglin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis A.","family":"Ennis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan L.","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4226-4232.1997"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.161.11.6338","article-title":"Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis","volume":"161","author":"Avirutnan P","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_1_4_1","first-page":"652","article-title":"Pathogenesis of dengue: an alternative hypothesis","volume":"21","author":"Bhakdi S","year":"1990","journal-title":"SE Asian J Trop Med Publ Health"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197311082891902"},{"key":"e_1_2_1_6_1","first-page":"551","article-title":"Comparison of the inhibitory effect of AcSDKP, TNF\u2010alpha, TGF\u2010beta, and MIP\u20101 alpha on marrow\u2010purified CD34+ progenitors","volume":"23","author":"Bonnet D","year":"1995","journal-title":"Exp Hematol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.38.172"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2646711"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.239.4839.476"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/265739a0"},{"key":"e_1_2_1_11_1","first-page":"311","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. 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