{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:18:24Z","timestamp":1785842304414,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T00:00:00Z","timestamp":1145491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infection is associated with high\u2010grade vulvar intraepithelial neoplasia (VIN\u20103). The prevalence of anogenital HPV infection in women with previously treated VIN\u20103 has not been documented yet. This cross\u2010sectional study compared high\u2010risk HPV DNA detection rates in women with past (n\u2009=\u200930) and current (n\u2009=\u200922) VIN\u20103 to those without current or past VIN (n\u2009=\u200986). HPV DNA was detected in vulvar and cervical samples with Hybrid Capture 2 (HC\u20102). Smoking was associated in multivariate analysis with current VIN\u20103 (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.0\u20138.2) and any VIN\u20103 history (OR 6.5, 95% CI 2.5\u201316.5). High\u2010risk HPV DNA was found on the vulva of 64%, 33%, and 20% of women with current VIN\u20103, past VIN\u20103, and without previous or current VIN, respectively. After controlling for age and smoking, high\u2010risk HPV vulvar infection was associated with cervical high\u2010risk HPV infection (OR 8.6, 95% CI 2.8\u201326.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). After controlling for age, HPV infection was more often multifocal in women with current VIN\u20103 compared to women with previous but no current VIN\u20103 lesion (OR 17.6, 95% CI 1.4\u2013227.2). Multifocal vulvar HPV infection was detected in women with previous or active VIN\u20103. Longitudinal studies are required to determine if the multifocality of HPV infection on the vulva could explain the high recurrence rate of VIN\u20103. J. Med. Virol. 78:814\u2013819, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20628","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T15:51:23Z","timestamp":1145548283000},"page":"814-819","source":"Crossref","is-referenced-by-count":36,"title":["High\u2010risk human papillomavirus infection of the genital tract of women with a previous history or current high\u2010grade vulvar intraepithelial neoplasia"],"prefix":"10.1002","volume":"78","author":[{"given":"Frederic","family":"Goffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Mayrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alobaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Drouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Coutl\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6466"},{"key":"e_1_2_1_3_1","first-page":"111","article-title":"Intraepithelial neoplasia and early stage vulvar cancer. 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