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The objective of this study was to estimate the HCV\u2010related morbidity in a rural area where mass schistosomiasis treatment campaigns took place 20\u201340 years before. The study sample included 2,425 village residents aged 18\u201365 years recruited through home\u2010based visits. Overall, HCV antibody prevalence was 448\/2,425\u2009=\u200918.5% (95% CI\u2009=\u200916.9\u201320.1%), reaching 45% in males over 40 years, and 30% in females over 50 years. Of those with HCV antibodies, 284\/448 (63.4%, 95% CI\u2009=\u200958.7\u201367.9%) had chronic HCV infection, among which 107\/266 (40.2%, 95% CI\u2009=\u200934.3\u201346.4%) had elevated alanine aminotransferase (ALT). As part of pre\u2010treatment screening, 26 consenting patients had a liver biopsy: 13 (50.0%) had a treatment indication. Thus, of all patients with HCV antibodies, 13 (2.9%) were eligible for treatment and willing to be treated. The relatively low level of morbidity observed in this study is discussed in view of co\u2010factors of HCV infection progression, such as young age at infection, absence of alcohol intake, the prevalence of<jats:italic>Schistosoma mansoni<\/jats:italic>infection, and the prevalence of chronic hepatitis B. J. Med. 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