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Growth curve experiments were conducted using cell lines that were possibly exhibited pathogenesis, and RT\u2010PCR and sequencing tests were undertaken to amplify the 5\u2032 non\u2010coding region (5\u2032\u2010NCR). The encephalitis isolate EV71 TW98NTU2078 was PBMC\u2010tropic, temperature\u2010resistant (Tr) at 40\u00b0C, and easier to replicate in HTB\u201014 (astrocytoma) than the herpangina isolate EV71 TW98NTU1186 (The viral yields were 100\u2010fold higher than those of the herpangina isolate EV71 TW98NTU1186 at 96 hr post infection.). The herpangina isolate EV71 TW98NTU1186 was non\u2010PBMC\u2010tropic, and temperature\u2010sensitive (Ts) at 40\u00b0C. The replication of EV71 TW98NTU1186 in HTB\u201014 was lower. No EV71 isolate infected HTB\u201037 (human colon adenocarcinoma cells). The encephalitis EV71 isolate exhibited better replication and transmission in PBMCs and astrocytes than did the EV71 isolate without CNS involvement. J. Med. Virol. 79:60\u201368, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20761","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T23:24:39Z","timestamp":1164756279000},"page":"60-68","source":"Crossref","is-referenced-by-count":40,"title":["Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in 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