{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:26:40Z","timestamp":1763224000454},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T00:00:00Z","timestamp":1174867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cross\u2010sectional study was carried out in healthy company employees from Greece with the aim of assessing the prevalence of human herpesvirus 8 (HHV\u20108) and identifying risk factors for this herpesviral infection. Serum samples obtained from 955 subjects were tested for antibodies to HHV\u20108 by the K8.1 enzyme\u2010linked immunosorbent assay (ELISA). Associations between HHV\u20108 serostatus and potential risk factors were examined using <jats:italic>t<\/jats:italic>\u2010test, chi square test, and multivariate logistic regression analysis. HHV\u20108 prevalence was 7.6% (95% confidence interval (CI): 6.0%, 9.5%) and it increased with age from 6.5% among &lt;30 years old to 13.8% among \u226550 years old subjects (<jats:italic>P<\/jats:italic>\u2009=\u20090.006). HHV\u20108 seropositivity was independently associated with endoscopic examination (odds ratio (OR): 2.01; 95% CI: 1.09, 3.70; <jats:italic>P<\/jats:italic>\u2009=\u20090.026), HBsAg positivity (OR: 5.16; 95% CI: 2.02, 13.20; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and age (OR \u226550 years old vs. &lt;50 years old: 2.09; 95% CI: 1.23, 3.52; <jats:italic>P<\/jats:italic>\u2009=\u20090.006). No statistically significant associations between HHV\u20108 positive status and gender, occupational status, surgery, transfusion, tattoos\/body piercing, multiple sex partners, weakness\/fatigue, HCV status were observed. HHV\u20108 is prevalent in Greece. The strong association between HBV infection and HHV\u20108 positive status supports the hypothesis of an association between these two viral infections. The association between HHV\u20108 seropositivity and endoscopic examination requires further investigation. J. Med. Virol. 79:591\u2013596, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20812","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T20:18:43Z","timestamp":1174940323000},"page":"591-596","source":"Crossref","is-referenced-by-count":18,"title":["Human herpesvirus 8 (HHV\u20108) infection in healthy urban employees from Greece: Seroprevalence and associated factors"],"prefix":"10.1002","volume":"79","author":[{"given":"Assimina","family":"Zavitsanou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vana","family":"Sypsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Petrodaskalaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Kalapothaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Whitby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Hatzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.5.465"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421407"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38898375517.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/315456"},{"key":"e_1_2_1_6_1","first-page":"207","article-title":"Seroprevalence and Kaposi's sarcoma\u2010associated herpesvirus\/human herpesvirus 8 in several regions of Italy","volume":"1","author":"Calabro ML","year":"1998","journal-title":"J Hum Virol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103013440904"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00490.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1182\/blood.V92.1.53.413k30_53_58","article-title":"Detection and titration of human\u2010herpesvirus\u20108\u2010specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi sarcoma patients using a whole virus enzyme\u2010linked immunosorbent assay","volume":"92","author":"Chatlynne LG","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_10_1","first-page":"535","article-title":"HHV\u20108 prevalence, immunosuppression and Kaposi's sarcoma in South Italy","volume":"7","author":"Crispo A","year":"2001","journal-title":"Int J Mol Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.3.194"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00042560-200004010-00011","article-title":"Identifying human herpesvirus 8 infection: Performance, characteristics of serologic assays","volume":"23","author":"Engels EA","year":"2000","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001215)88:6<1003::AID-IJC26>3.0.CO;2-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199902)57:2<159::AID-JMV12>3.0.CO;2-A"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200106150-00012"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200306010-00015"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90641-X"},{"key":"e_1_2_1_18_1","first-page":"2119","article-title":"Seroprevalence of Kaposi's sarcoma\u2010associated herpesvirus in healthy adults in Israel","volume":"20","author":"Iscovich J","year":"2000","journal-title":"Anticancer Res"},{"key":"e_1_2_1_19_1","first-page":"570","article-title":"Mediterranean Kaposi's sarcoma: Preliminary communication about 131 cases","volume":"77","author":"Kaloterakis A","year":"1984","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-918"},{"key":"e_1_2_1_21_1","first-page":"79","article-title":"Prevalence of antibodies to HHV\u20108 in the general population and in individuals at risk for sexually transmitted and blood\u2010borne infections in Catania, Eastern Sicily","volume":"13","author":"Larocca L","year":"2005","journal-title":"Infez Med"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804023381403"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<817::AID-IJC2>3.0.CO;2-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980812)77:4<543::AID-IJC12>3.0.CO;2-7"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2003.24"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011093431904"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.1.175"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/515649"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000027358.38997.66"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-7-1573"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015678312153"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07560-5"},{"key":"e_1_2_1_33_1","first-page":"1","article-title":"Kaposi's sarcoma in South Africa","volume":"28","author":"Sitas F","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402403"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2004.00061.x"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4857-7_74"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015671627577"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970304)70:5<538::AID-IJC8>3.0.CO;2-Z"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800004726"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a024173"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199809000-00007"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91619-9"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9674"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.20812","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.20812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:16:19Z","timestamp":1700043379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.20812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,26]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/jmv.20812"],"URL":"https:\/\/doi.org\/10.1002\/jmv.20812","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,26]]}}}