{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:19Z","timestamp":1786978039355,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Like other herpesviruses, human herpesvirus 6 (HHV\u20106) can reactivate in immunocompromised patients. A case is described of an HIV\u20101\u2010infected patient who developed bilateral retrobulbar optic neuritis associated with HHV\u20106 infection. A 59\u2010year\u2010old woman, infected with HIV for 18 years, interrupted antiretroviral treatment because of therapeutic failure and severe metabolic complications. She presented subsequently with blurred vision and ophthalmological examination showed visual loss due to optic neuritis. Her CD4+ count was 285 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    and her plasma HIV\u20101 RNA level was 5.5 log\n                    <jats:sub>10<\/jats:sub>\n                    copies (cp)\/ml. Magnetic resonance imaging of the brain was normal. HHV\u20106 loads were 3.2 log cp\/ml in cerebrospinal fluid (CSF) and 6.3 log cp\/10\n                    <jats:sup>6<\/jats:sup>\n                    peripheral blood mononuclear cells. Combined intravenous treatment was started with foscarnet and ganciclovir then changed to cidofovir and long\u2010term valganciclovir. Her ocular condition improved gradually despite little decrease of the HHV\u20106 load in the CSF. Salvage antiretroviral treatment was then administered, with marked immunological and virological responses, contributing to further progressive ocular improvement. HHV\u20106\u2010related optic neuritis has not been described previously in HIV\u2010infected patients. Anti\u2010HHV\u20106 treatment improved the patient's vision, but immune restoration seems to remain essential for long\u2010term recovery. J. Med. Virol. 79:931\u2013934, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jmv.20833","type":"journal-article","created":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T02:24:56Z","timestamp":1179800696000},"page":"931-934","source":"Crossref","is-referenced-by-count":19,"title":["Human herpesvirus 6\u2010associated retrobulbar optic neuritis in an HIV\u2010infected patient: response to anti\u2010herpesvirus therapy and long\u2010term outcome"],"prefix":"10.1002","volume":"79","author":[{"given":"Fr\u00e9d\u00e9ric","family":"M\u00e9cha\u00ef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boutolleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Manceron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Gasnault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Quertainmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Brosseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Delfraissy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Labetoulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Goujard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280591002379"},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Fatal 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