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HCV\u2010specific T\u2010cell responses were examined in 92 interferon\u2010naive individuals with chronic hepatitis C. A panel of 441 overlapping peptides spanning all expressed HCV proteins was used to measure HCV\u2010specific T\u2010cell responses, using flow cytometry after stimulating peripheral blood mononuclear cells (PBMCs) with different pools of these peptides. Most patients showed responses to at least one HCV protein, with NS5B for CD8+ responses and E2 for CD4+ responses identified most frequently. Both the prevalence and breadth of CD4+ and CD8+ responses were lower in co\u2010infected patients, independently of the HCV genotype. J. Med. Virol. 79:503\u2013510, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20856","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T20:17:50Z","timestamp":1174940270000},"page":"503-510","source":"Crossref","is-referenced-by-count":20,"title":["Influence of HCV genotype and co\u2010infection with human immunodeficiency virus on CD4+ and CD8+ T\u2010cell responses to hepatitis C 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