{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:27:12Z","timestamp":1789273632410,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T00:00:00Z","timestamp":1183334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 42\u2010year\u2010old male with stage IV mantle cell lymphoma received chemotherapy and autologous peripheral blood stem cell transplantation. He developed pancytopaenia, and bone marrow examination indicated a parvovirus B19 (PVB 19)\u2010induced red cell aplasia, confirmed by virological tests. Multiple doses of intravenous immunoglobulin (IVIG) were given over the following months, with blood samples being taken after each dose for quantitative PVB 19 DNA and hematological testing to assess the response. Each dose of IVIG produced a 1\u20133 log<jats:sub>10<\/jats:sub> drop in PVB 19 DNA levels. Eventually, after the fifth dose of IVIG, the PVB 19 DNA was reduced to &lt;10 copies\/ml serum, with a gradual improvement in his hematological parameters. This report demonstrates how close monitoring of the virological and hematological response to IVIG therapy for persistent PVB 19 infection in an immunocompromised patient can optimize the usage of this relatively expensive, and sometimes scarce intervention. J. Med. Virol. 79:1401\u20131405, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20870","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T01:21:46Z","timestamp":1183425706000},"page":"1401-1405","source":"Crossref","is-referenced-by-count":15,"title":["Dose\u2010by\u2010dose virological and hematological responses to intravenous immunoglobulin in an immunocompromised patient with persistent parvovirus B19 infection"],"prefix":"10.1002","volume":"79","author":[{"given":"Julian W.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June S.M.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Y.N.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo L.K.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.F.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830440314"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00221.x"},{"key":"e_1_2_1_4_1","first-page":"47","article-title":"Relapsing pure red cell aplasia associated with B\u2010cell chronic lymphocytic leukemia successfully treated by intravenous immunoglobulin concentrate","volume":"17","author":"Castelli R","year":"2002","journal-title":"Ann Ital Med Int"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.395"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655402753395247"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00792.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/504812"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00227.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03741.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.485-505.2002"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2001.0882"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20200"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1125"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.602-614.2000"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200101150-00010"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199712270-00037"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.10.004"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05250.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood.V96.3.1184.015k54_1184_1186","article-title":"Pure red cell aplasia due to parvovirus B19 in a patient treated with rituximab","volume":"96","author":"Sharma VR","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03778.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41121500.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00282-997-0199-9"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1993.tb00152.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70021-1"},{"key":"e_1_2_1_26_1","first-page":"59","article-title":"Does intravenous immune globulin have a role in HIV\u2010infected patients?","volume":"97","author":"Yap PL","year":"1994","journal-title":"Clin Exp Immunol"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.20870","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.20870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T19:37:56Z","timestamp":1699990676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.20870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,2]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/jmv.20870"],"URL":"https:\/\/doi.org\/10.1002\/jmv.20870","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,2]]}}}