{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:21:45Z","timestamp":1777263705317,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T00:00:00Z","timestamp":1177372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute hemorrhagic conjunctivitis is associated with enteroviruses. Among these, Coxsackie A\u201024 variant (CA\u201024) and Enterovirus\u201070 (EV\u201070) are known to cause epidemics and pandemics. An outbreak of acute hemorrhagic conjunctivitis occurred in August\u2013September 2003 in Maharashtra and Gujarat states of India. The present investigation was carried out to determine the viral etiological agent associated with the epidemic. Virus isolates were obtained from 11 eye swabs of conjunctivitis patients using HeLa\/ Hep\u20102 cell lines. The isolates were characterized by serological and mouse pathogenecity tests, RT\u2010PCR using enterovirus common primers (VP4\u2010VP2), CA\u201024 specific primers (3C\u2010proteinase region), EV\u201070 primers (VP\u20103) followed by sequencing, and phylogenetic analysis. The virus was characterized as a Coxsackie A\u201024 variant (CA\u201024v) and none of the isolates were found to be positive for EV\u201070. Sequencing of the PCR products derived from all the 11 isolates revealed 98.4% (SE 0.20) nucleotide identity within the Indian strains and 98.6% (0.50) and 94.4% (0.30) nucleotide identity respectively with the West Indies and Asian strains reported worldwide. The findings suggest that the outbreak of acute hemorrhagic conjunctivitis that occurred in Maharashtra and Gujarat states of India during August\u2013September 2003 was caused by the Coxsackie A\u201024 variant (CA\u201024v). J. Med. Virol. 79: 748\u2013753, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20886","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T22:48:44Z","timestamp":1177454924000},"page":"748-753","source":"Crossref","is-referenced-by-count":30,"title":["Outbreak of acute hemorrhagic conjunctivitis in Maharashtra and Gujarat states of India, caused by coxsackie virus A\u201024 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