{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:19:22Z","timestamp":1791292762342,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,23]],"date-time":"2001-10-23T00:00:00Z","timestamp":1003795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>GB virus\u2010B (GBV\u2010B) is a member of the Flaviviridae family of viruses. This RNA virus causes acute resolving hepatitis in experimentally infected tamarins, but its natural host remains unknown. GBV\u2010B and a related virus, GBV\u2010A, were recovered from serum containing the \u201cGB agent,\u201d which was believed to have originated from a surgeon (initials: GB) with acute hepatitis. GBV\u2010B has special interest because it is the virus related most closely to hepatitis C virus, which is an important cause of acute and chronic liver disease in humans. In the present study, we found that the host range of GBV\u2010B includes owl monkeys. Tamarins and owl monkeys belong to two different families of New World monkeys. The natural history of GBV\u2010B in the two owl monkeys studied was similar to that previously found for tamarins and was characterized by early appearance of viremia and viral clearance. However, the peak viral titers of GBV\u2010B observed in owl monkeys (10<jats:sup>5<\/jats:sup> genome equivalents [GE] \/ml) were lower than those observed in experimentally infected tamarins (10<jats:sup>7<\/jats:sup>\u201310<jats:sup>8<\/jats:sup> GE\/ml) and acute hepatitis was observed in only one animal. If GBV\u2010B were indeed a virus of humans, it would be expected to infect chimpanzees, a surrogate of humans, because all recognized human hepatitis viruses are transmissible to chimpanzees and cause hepatitis. However, in the present study, we failed to transmit GBV\u2010B to a naive chimpanzee. In addition, a second naive chimpanzee transfected intrahepatically with RNA transcripts from an infectious clone of GBV\u2010B did not become infected. Thus, chimpanzees are apparently not susceptible to GBV\u2010B. Finally, we failed to detect GBV\u2010B in acute\u2010phase serum from surgeon GB. Our data suggest that GBV\u2010B is not a human virus and that GBV\u2010B, like GBV\u2010A, is a virus of New World monkeys. J. Med. Virol. 65:694\u2013697, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.2092","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:17:12Z","timestamp":1030310232000},"page":"694-697","source":"Crossref","is-referenced-by-count":76,"title":["Host range studies of GB virus\u2010B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees\u2020"],"prefix":"10.1002","volume":"65","author":[{"given":"Jens","family":"Bukh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl L.","family":"Apgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugantha","family":"Govindarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8461"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/515255"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9941"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.125.4.673"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-1-41"},{"key":"e_1_2_1_7_1","first-page":"1035","volume-title":"Fields Virology","author":"Houghton M","year":"1996"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1128\/jvi.69.9.5621-5630.1995","article-title":"Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis","volume":"69","author":"Muerhoff AS","year":"1995","journal-title":"J Virol"},{"key":"e_1_2_1_9_1","first-page":"931","volume-title":"Fields Virology","author":"Rice CM","year":"1996"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050479"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890460117"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92821-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0695-564"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3401"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890050202"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9092"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.2092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.2092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:12:33Z","timestamp":1700406753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.2092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,23]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/jmv.2092"],"URL":"https:\/\/doi.org\/10.1002\/jmv.2092","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,23]]}}}