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Of the 25 infants in the control group, 5 were infected with HCMV but without hepatitis, 10 had hepatitis but no HCMV infection, and 10 were healthy. Proteomic expression in the serum was detected by WCX2 chips and surface\u2010enhanced laser desorption\/ionization time\u2010of\u2010flight mass spectrometry (SELDI\u2010TOF\u2010MS), to identify serum protein biomarkers in infants with hepatitis syndrome resulting from HCMV. Fifteen protein peaks were distinctly different among the four groups in the mass range from 2,000 to 20,000 Da. Of these 15 peaks, 4 at 4,349.8, 5,808.7, 7,935.6, and 8,885.9 Da were significantly different between the congenital HCMV\u2010infected infants with hepatitis and the controls. Five peaks were distinctly up\u2010regulated in the infants with HCMV infection (3,266.8, 5,638.5, 5,909.1, 7,771.4, and 15,835.6 Da) compared to those without HCMV infection. Two proteins at 4,600.1 and 5,704.3 were up\u2010regulated in infants with HMCV infection but no hepatitis. Four protein peaks were markedly different (7,567.0, 13,744.8, 15,100.7, and 15,915.0 Da) between the infants with hepatitis and the other controls. Comparison of the differentially expressed proteins' properties with those available on an international database suggest that specific serum proteins such as the augmenter of liver regeneration, pre\u2010albumin, and haptoglobin closely related to liver function, and cytokines such as beta\u2010defensins 31 and 8, and macrophage\u2010derived chemokine, among others, are involved in HMCV infection and the pathogenesis of HMCV\u2010induced hepatitis in infants. J. Med. Virol. 79:1500\u20131505, 2007. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20927","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T16:19:02Z","timestamp":1187367542000},"page":"1500-1505","source":"Crossref","is-referenced-by-count":11,"title":["Serum proteomics with SELDI\u2010TOF\u2010MS in congenital human cytomegalovirus 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