{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:49:02Z","timestamp":1744357742647},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T00:00:00Z","timestamp":1183334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal allograft recipients in the Middle East are at high risk of developing Kaposi's sarcoma. This report describes the extent of oral human herpesvirus 8 shedding and the genomic diversity of the virus in five Saudi Arabian kidney transplantation patients in whom Kaposi's sarcoma had developed. PCR protocols were applied to amplify three fragments of the viral genome from whole\u2010mouth saliva, parotid saliva, buccal and palatal exfoliates, plasma, peripheral blood leukocytes and biopsy of the Kaposi's sarcoma lesion, and to quantify the viral load in whole\u2010mouth saliva. Viral DNA was detected in all plasma and biopsy samples, 80% of whole\u2010mouth saliva, 20% of each of the other oral samples, and none of the leukocyte samples. The viral load in the cell\u2010free fraction of whole\u2010mouth saliva ranged between approximately 1.2\u2009\u00d7\u200910<jats:sup>3<\/jats:sup> and 2.2\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> genome\u2010copies\/ml. Genotypically distinct viral strains were evident: intra\u2010lesionally in 1 patient; intra\u2010orally in one patient; between an oral sample and biopsy in two patients; and in four patients, between an oral sample and plasma, and between plasma and biopsy. Thus, in the patients studied, salivary shedding of human herpesvirus 8 was frequent and could be extensive, and they were prone to multiple infections. Measures to curtail salivary viral transmission to pre\u2010 and post\u2010transplantation patients might reduce the incidence of post\u2010transplantation Kaposi's sarcoma. J. Med. Virol. 79:1357\u20131365, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20929","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T01:26:26Z","timestamp":1183425986000},"page":"1357-1365","source":"Crossref","is-referenced-by-count":16,"title":["Salivary human herpesvirus 8 shedding in renal allograft recipients with Kaposi's sarcoma"],"prefix":"10.1002","volume":"79","author":[{"given":"L.M.","family":"Al\u2010Otaibi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Ngui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Scully","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"46","article-title":"Kaposi's sarcoma in renal transplant recipients","volume":"4","author":"al Sulaiman MH","year":"1994","journal-title":"Transplant Sci"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/377504"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/517356"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/374599"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/509621"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.04.030"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(02)00123-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-7-1613"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.3.703"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.4074-4084.2004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6135.2003.00276.x"},{"key":"e_1_2_1_13_1","first-page":"339","article-title":"Kaposi's sarcoma in organ transplant recipients. 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