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Four hundred eighty\u2010seven genes exhibited differential expression levels; 456 of these genes were up\u2010regulated while 31 genes were down\u2010regulated. We identified 53 biological processes that were significantly relevant to the RV\u2010infection. Among these biological processes, 52 were one\u2010gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif\u2010containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon\u2010induced genes. These results suggest that genes relevant to interferon\u2010regulated pathways may be involved in the pathogenesis of rubella. J. Med. Virol. 79:1783\u20131791, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.20942","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T16:47:11Z","timestamp":1189702031000},"page":"1783-1791","source":"Crossref","is-referenced-by-count":21,"title":["Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella 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