{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:32:06Z","timestamp":1790890326134,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The seroprevalence rates of human immunodeficiency virus (HIV), human T\u2010cell leukemia\/lymphoma virus (HTLV), hepatitis B virus (HBV), hepatitis D virus (HDV), and hepatitis C virus (HCV) in Mozambique are poorly documented. The epidemiology of these infections was studied in the Maputo region. All donors attending the blood bank during the study period were interviewed and underwent serological and molecular tests for markers of virus exposure. Thus, 1,578 consecutive replacement blood donors were investigated, as they undergo no selection (other than their relation with a patient needing a transfusion), and may thus provide reliable estimates of the prevalence rates in the general population. The age\u2010standardized prevalence rates among 15\u2010 to 49\u2010year\u2010old men and women were, respectively, 12.3 and 15.4% for HIV and 0.9 and 1.2% for HTLV. Low educational status (<jats:italic>P<\/jats:italic>\u2009=\u20090.014) and tattooing\/scarification (<jats:italic>P<\/jats:italic>\u2009=\u20090.023) were predictive of HIV infection in multivariate analysis. The age\u2010adjusted prevalence rates of markers of hepatotropic virus among men and women were, respectively, 10.6 and 4.5% for hepatitis B surface antigen (HBsAg), 1.2 and 1.0% for anti\u2010HCV, and 0 and 0% for anti\u2010HDV. Two percent of donors had viral co\u2010infections, involving most frequently the combination of HIV and HBsAg +. A significant association was found between anti\u2010HIV and anti\u2010HBc (<jats:italic>P<\/jats:italic>\u2009=\u20090.012). HBsAg was associated with the place of birth (<jats:italic>P<\/jats:italic>\u2009=\u20090.011) and a history of transfusion (<jats:italic>P<\/jats:italic>\u2009=\u20090.069). Smokers had higher seroprevalence rates than nonsmokers for HIV (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and HBsAg (<jats:italic>P<\/jats:italic>\u2009= 0.045). Genotype A was the most frequent HBV genotype (86.3%) followed by E and D. HCV genotypes were 1a, 1b, 3a, and 5a. These results show that HBV vaccination and HIV\u2010preventive measures need to be reinforced in Mozambique. J. Med. Virol. 79:1832\u20131840, 2007. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21010","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T17:17:48Z","timestamp":1192209468000},"page":"1832-1840","source":"Crossref","is-referenced-by-count":67,"title":["Use of replacement blood donors to study the epidemiology of major blood\u2010borne viruses in the general population of Maputo, Mozambique"],"prefix":"10.1002","volume":"79","author":[{"given":"Lina","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Plouzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ingrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl Paulo 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