{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:01:48Z","timestamp":1774792908510,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T00:00:00Z","timestamp":1198108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The implication of genotypes is recognized increasingly in the clinical course of hepatitis B virus (HBV) and in response to anti\u2010viral drugs of hepatitis C virus (HCV). Genotypic prevalence of both etiological agents varies geographically and no data are available for Tajikistan. To investigate the epidemiology and clinical significance of HBV and HCV genotypes in chronic hepatitis (group 1) and liver cirrhosis\/hepatocellular carcinoma (HCC) (group 2) patients in Tajikistan, 124 patients with chronic liver disease (group 1\u2009=\u200984 and group 2\u2009=\u200940) were enrolled. Genotypes of HBV, HCV, and delta hepatitis virus (HDV) were determined by sequencing. The overall prevalence of anti\u2010HCV, HCV core antigen (HCVcAg) and HBsAg was 46% (57\/124) and 41.1% (51\/124), respectively. Coinfection of HCV\/HBV, HBV\/HDV, and HCV\/HBV\/HDV was found in 4.8% (6\/124), 11.2% (12\/124), and 0.8% (1\/124) of cases, respectively. HDV genotype 1 was found in 19.6% (10\/51) of HBsAg\u2010positive patients. The HBV\/HDV coinfection was relatively high in group 2 compared to group 1 (15% vs. 7.1%). HCV\/1b detected in 84.6% (44\/52) of HCV RNA\u2010positive patients, followed by 3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV\/D was detected in 94.1% (48\/51) of HBsAg\u2010positive patients, followed by HBV\/A [5.8% (3\/51)]. T1762\/A1764 double mutation was associated with liver cirrhosis\/HCC in HBV\u2010infected patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.0004). This is the first study on the molecular epidemiology of hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV\u2010infected patients, the T1762\/A1764 mutation was associated with liver cirrhosis\/HCC. J. Med. Virol. 80:268\u2013276, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21057","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T17:21:46Z","timestamp":1198171306000},"page":"268-276","source":"Crossref","is-referenced-by-count":36,"title":["Epidemiological and clinical evaluation of hepatitis B, hepatitis C, and delta hepatitis viruses in 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