{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:06:20Z","timestamp":1790924780459,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T00:00:00Z","timestamp":1203638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug users and particularly, injecting drug users, are at increased risk for infection with hepatitis C virus (HCV). The aims of the study were to simultaneously detect HCV core antigen and specific antibodies in sera from Saudi drug users using the new HCV combination assay and to compare this data with HCV core antigen, anti\u2010HCV antibodies and HCV RNA data from the same patients. A total of 297 patients who are followed up or admitted to a drug rehabilitation hospital over a period of 3 years were included in this study. Samples were analyzed using the new HCV Ag\/Ab combination assay (Meurex), HCV core Ag assay, HCV antibodies and with the HCV RNA assay. Out of the 297 samples from Saudi drug users, 111 samples (37.4%) have detectable HCV core Ag, 112 samples (37.7%) have detectable HCV antibodies, 118 have detectable HCV RNA, and 116 samples were positive by the HCV Ag\/Ab combination assay (39.1%). Out of the 116 samples, HCV core Ag was detected in 110 samples (94.8%), HCV antibodies were detected in 111 (95.7%) samples and HCV RNA was detected in 114 samples (98.3%). In the control group (n\u2009=\u2009305), only 2 (0.66%) blood donor were positive by HCV antibodies assay, HCV RNA assay as well as HCV Ag\/Ab combination assay. The new HCV Ag\/Ab combination assay may well improve the overall quality of diagnosis of HCV infection especially in high risk population such as drug users that necessitates rigorous testing. J. Med. Virol. 80:603\u2013606, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21075","type":"journal-article","created":{"date-parts":[[2008,2,23]],"date-time":"2008-02-23T02:46:44Z","timestamp":1203734804000},"page":"603-606","source":"Crossref","is-referenced-by-count":20,"title":["Simultaneous detection of hepatitis C virus core antigen and antibodies in Saudi drug users using a novel assay"],"prefix":"10.1002","volume":"80","author":[{"given":"Alhusain J.","family":"Alzahrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1157\/13099368"},{"key":"e_1_2_1_3_1","first-page":"1645","article-title":"Analysis of HCV core antigenemia in Saudi Drug users","volume":"26","author":"Alzahrani AJ","year":"2005","journal-title":"Saudi Medic J"},{"key":"e_1_2_1_4_1","first-page":"103","article-title":"Detection of hepatitis C virus core antigen in blood donors using a new enzyme immunoassay","volume":"11","author":"Alzahrani AJ","year":"2004","journal-title":"FAMCO J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00646.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21321"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40101198.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.414-420.2005"},{"key":"e_1_2_1_9_1","first-page":"S120","article-title":"Prevalence of hepatitis C virus infection in the Eastern Province of Saudi Arabia DNA and second generation and supplemental EIA tests","volume":"24","author":"Fathalla S","year":"2003","journal-title":"Saudi Medic J"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00668-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3877-3883.2005"},{"key":"e_1_2_1_12_1","first-page":"S286","article-title":"Chronic hepatitis C: An age wave of disease burden","volume":"11","author":"McHutchison JG","year":"2005","journal-title":"Am J Manag Care"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.92.3.385"},{"key":"e_1_2_1_14_1","first-page":"89","article-title":"Prevalence of antibodies to hepatitis C virus in drug\u2010dependent patients in Jeddah, Saudi Arabia","volume":"74","author":"Njoh J","year":"1997","journal-title":"East Afr Med J"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1002\/hep.1840360709","article-title":"Use and interpretation of virological tests for hepatitis C","volume":"36","author":"Pawlotsky JM","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.07.008"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200111000-00014"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1561-1563.2006"},{"key":"e_1_2_1_19_1","first-page":"S133","article-title":"Hepatitis C infection among drug addicts","volume":"24","author":"Shawky S","year":"2003","journal-title":"Saudi Medic J"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.186-191.2005"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21075","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T18:18:54Z","timestamp":1738088334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,22]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/jmv.21075"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21075","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,22]]}}}