{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:32:55Z","timestamp":1790778775015,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T00:00:00Z","timestamp":1200614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Most adults have persistent Epstein\u2013Barr virus (EBV)\u2010infection. Adolescents and young adults with primary EBV\u2010infection frequently develop infectious mononucleosis. Latent EBV\u2010infection is associated with various diseases, neoplasms, and hematological disorders. In vivo animal models of human EBV infection, such as non\u2010human primates, have had limited success. A new rabbit model for primary human EBV\u2010infection is described in this study. Seven male rabbits inoculated intravenously with EBV were sequentially imaged by ultrasonography and computed tomography, and examined for anti\u2010EBV\u2010VCA titer and EBV\u2010DNA levels in blood. Six rabbits demonstrated transient splenomegaly, increased anti\u2010EBV\u2010VCA titers and\/or EBV\u2010DNA in blood. Transient infiltration of some EBER1\u2010positive lymphocytes was observed in biopsied liver tissues. After splenomegaly, two rabbits tested continuously negative, two alternatively positive and negative, and one consistently positive EBV detection in blood for 470 days. One tested negative for both EBV DNA and splenomegaly. On the 14\n                    <jats:sup>th<\/jats:sup>\n                    day, mild to moderate numbers of EBER1\u2010positive lymphocytes expressing LMP1, EBNA2, or ZEBRA infiltrated mainly in enlarged white pulps of two splenectomized materials. These cells included both B and T cells. EBV clonality analysis revealed an oligoclonal pattern. These indicate that EBV\u2010inoculated rabbits exhibiting heterogenous host reactions are a good model for primary and persistent human EBV infection. J. Med. Virol. 80:455\u2013466, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jmv.21102","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T20:46:26Z","timestamp":1200689186000},"page":"455-466","source":"Crossref","is-referenced-by-count":32,"title":["A new animal model for primary and persistent Epstein\u2013Barr virus infection: Human EBV\u2010infected rabbit characteristics determined using sequential imaging and pathological analysis"],"prefix":"10.1002","volume":"80","author":[{"given":"Kazuaki","family":"Takashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukisato","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sairenji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"239","article-title":"Detection and characterization of Epstein\u2010Barr virus in clinical specimens","volume":"145","author":"Ambinder RF","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5710(96)00532-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4450"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199203000-00037"},{"key":"e_1_2_1_7_1","first-page":"141","article-title":"Malignant lymphoma induction in rabbits by oral inoculation of crude virus fraction prepared from Ts\u2010B6 cells (cynomolgus B\u2010lymphoblastoid cells harboring Epstein\u2010Barr virus\u2010related simian herpesvirus)","volume":"51","author":"Chen HL","year":"1997","journal-title":"Acta Med Okayama"},{"key":"e_1_2_1_8_1","first-page":"35","volume-title":"Clinical aspects of Epstein\u2010Barr virus infection","author":"Cohen J","year":"2005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_1_10_1","first-page":"204","article-title":"The Epstein\u2010Barr virus in the pathogenesis of posttransplant lymphoproliferative disorders. 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