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The unexpected emergence of WNV (New York, 1999) and its rapid spread throughout North America during the following years caused a number of blood transfusion\u2010 and organ transplant\u2010associated transmissions of WNV. In order to estimate the potential WNV threat for Central Europe, we analyzed the anti\u2010WNV prevalence and WNV\u2010RNA incidence among 14,437 and 9,976 blood donors from Germany. There was a high rate of initially anti\u2010WNV reactives (5.9%), but only a few cases (0.03%) were confirmed as anti\u2010WNV positive by neutralization assay. No WNV\u2010RNA positive blood donor was identified in this study. Whereas WNV\u2010RNA was frequently detected in manufacturing plasma pools from the US, none was detected in pools of European or Asian origin. Virus inactivation steps integrated into the manufacturing process of plasma derivatives were shown to be sufficient to assure the WNV safety of plasma derivatives. A well\u2010characterized WNV reference material was prepared, showing 340 WNV\u2010RNA copies per infectious dose. J. Med. Virol. 80:557\u2013563, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21110","type":"journal-article","created":{"date-parts":[[2008,1,19]],"date-time":"2008-01-19T01:50:53Z","timestamp":1200707453000},"page":"557-563","source":"Crossref","is-referenced-by-count":18,"title":["West Nile virus and blood product safety in Germany"],"prefix":"10.1002","volume":"80","author":[{"given":"Christa","family":"Pfleiderer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bl\u00fcmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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