{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:49:29Z","timestamp":1762865369009},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T00:00:00Z","timestamp":1203638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lymphoblastic leukemia is the main type of leukemia in children. An infectious etiology has been suspected and the role of the Human herpesvirus\u20106 (HHV\u20106) has been suggested. Several studies have tried to establish a link between HHV\u20106 infections and hematological malignancies, with discordant results. The potential role of HHV\u20106 in the pathogenesis of pediatric acute lymphoblastic leukemia was investigated. HHV\u20106 genome copy number was measured by quantitative real\u2010time PCR (RQ\u2010PCR) in bone marrow or peripheral blood samples obtained from 36 children (median age\u2009=\u20094 years) with B acute lymphoblastic leukemia (n\u2009=\u200931) and T acute lymphoblastic leukemia (n\u2009=\u20095) at diagnosis and during complete remission. Positive samples were further characterized to define viral variant, A or B. A total of 24.7% of samples were positive for HHV\u20106 genome: 13.9% were leukemia samples and 34.1% were complete remission samples. Viral load was low with values lower at diagnosis (median viral copy number\u2009=\u200922.9) than at complete remission (median copy number\u2009=\u200960.1). Among the 17 patients with positive samples, 15 were typed as B\u2010variant whereas 2 could not be typed. These results argue against a role of HHV6 infection in the development of pediatric acute lymphoblastic leukemia. They also suggest that HHV\u20106 may infect latently bone marrow progenitors but seems not able to infect leukemic cells, raising again the question of the mechanism of virus fusion and entry. This observation shows that a reactivation may be observed during complete remission supporting the possibility of virus reactivation in immunocompromised hosts. J. Med. Virol. 80:689\u2013693, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21118","type":"journal-article","created":{"date-parts":[[2008,2,23]],"date-time":"2008-02-23T02:46:26Z","timestamp":1203734786000},"page":"689-693","source":"Crossref","is-referenced-by-count":19,"title":["Quantitation of human herpes virus 6 genome in children with acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"80","author":[{"given":"Elisa","family":"Seror","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9r\u00e9nice","family":"Coquerel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Gautheret\u2010Dejean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Landman\u2010Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Leverger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Vannier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80319-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204004"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.08.002"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.217-245.2005"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00390-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03700.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402748"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/318142"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.7.982"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92148-U"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61483-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.754-759.1999"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05166.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(99)00079-X"},{"key":"e_1_2_1_16_1","first-page":"1365","article-title":"Oncogenic potential of human herpesvirus\u20106 DNA","volume":"5","author":"Razzaque A","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2876520"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81678-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1571-1574.2006"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)09403-9"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042207"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:05:26Z","timestamp":1700006726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,22]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/jmv.21118"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21118","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,22]]}}}