{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:35:47Z","timestamp":1773318947810,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral\u2010fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in Korea, the VP3\/VP1 and VP1\/P2A junction regions were detected by RT\u2010PCR from HAV IgM positives during 2005 and 2006. Among 160 HAV IgM positive sera, 30% (n\u2009=\u200948) were positive for HAV RNA. Additionally, the VP3\/VP1 junction regions were detected all six stools, which collected from outbreak in Gyeonggi province. Phylogenetic analysis of the sequences obtained from 54 distinct HAV isolates revealed that most of the strains (n\u2009=\u200945) belonged to genotype IA and the others including nine strains belonged to genotype IIIA. Interestingly, a Q\u2009\u2192\u2009S amino acid change was dominantly observed at position 810 of the VP1\/P2A junction region in 14 isolates. The molecular epidemiology of HAV infection in Korea has changed with the co\u2010circulation of at least two genotypes and 810Q\u2009\u2192\u2009S amino acid substitutions were found to be prevalent. These results strongly suggest that various HAV strains, including genotype IIIA, might be imported from high\u2010endemic countries into Korea. J. Med. Virol. 80:777\u2013784, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21127","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T23:16:51Z","timestamp":1206141411000},"page":"777-784","source":"Crossref","is-referenced-by-count":37,"title":["Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005\u20132006"],"prefix":"10.1002","volume":"80","author":[{"given":"Haesun","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeokjin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Soo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Joon","family":"Yim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Suk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngmee","family":"Jee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"760","article-title":"Molecular characterization of hepatitis A virus from a large outbreak from Kerala, India","volume":"123","author":"Arankalle VA","year":"2006","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/315701"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(20000201)63:2<88::AID-JMV1001>3.0.CO;2-G"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02481.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10402"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.6.2825-2828.2004"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2025"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19532-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2106"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(02)00248-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20101"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/319688"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2006.08.001"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.01.014"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.2867"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890360208"},{"key":"e_1_2_1_18_1","first-page":"114","article-title":"Moelcular epidemiology of an outbreak of Hepatitis A in Korea","volume":"21","author":"Kim JS, Kim SH","year":"2001","journal-title":"Korean J Clin Pathol"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10194"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.63-79.2006"},{"key":"e_1_2_1_21_1","first-page":"276","article-title":"Molecular epidemiology of Korean strains of hepatitis A virus","volume":"6","author":"Park SH, Byun KS","year":"2000","journal-title":"Korean J Hepatol"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-12-2955"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.2.286"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-6-1365"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4148-4155.2002"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2000.41.1.34"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655498750002277"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199704)51:4<273::AID-JMV3>3.0.CO;2-2"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20464"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.03.008"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/381152"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T08:47:24Z","timestamp":1700038044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,21]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/jmv.21127"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21127","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,21]]}}}