{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:19:13Z","timestamp":1778602753772,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T00:00:00Z","timestamp":1208736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this prospective study was to investigate the role of HHV\u20106 infection in children with acute onset of liver failure using real\u2010time quantitative PCR. Twenty\u2010three children (median age, 24 months) were included: 6 cases of fulminant hepatic failure of undetermined cause (group 1); 4 cases of fulminant hepatic failure of recognized cause (group 2); 3 cases of acute decompensation of chronic liver disease (group 3); and 10 cases of chronic liver disease (group 4). HHV\u20106 genomic DNA was detected and quantified using real\u2010time PCR in plasma and livers obtained at the time of transplantation. HHV6\u2010DNA detection rate was significantly higher among groups 1, 2, and 3 compared to group 4 (76.9% vs. 20% <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Viral loads ranged from 6 to 32,500 copies\/106 cells. Significantly higher viral loads were found in 4 of 9 children with acute onset of liver failure of unknown origin (group 1, n\u2009=\u20093; group 3, n\u2009=\u20091) and 1 child with fulminant autoimmune hepatitis (group 2) (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). These results strongly support the hypothesis that HHV\u20106 may cause fulminant hepatic failure and acute decompensation of chronic liver disease in children. Nevertheless, a threshold viral load value still remains to be determined. J. Med. Virol. 80:1051\u20131057, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21143","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T17:49:49Z","timestamp":1208800189000},"page":"1051-1057","source":"Crossref","is-referenced-by-count":40,"title":["Human herpesvirus\u20106 infection: A prospective study evaluating HHV\u20106 DNA levels in liver from children with acute liver failure"],"prefix":"10.1002","volume":"80","author":[{"given":"Laurent","family":"Chevret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Boutolleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Halimi\u2010Idri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Branchereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Baujard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Gautheret\u2010Dejean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Debray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316913"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90983-C"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.12.1484"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.93.1.104"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1128\/jcm.29.2.367-372.1991","article-title":"Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction","volume":"29","author":"Aubin JT","year":"1991","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.10.2434-2440.1994"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10552"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/367677"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20345"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01567.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(96)01364-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7440"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.31.2.416-418.1993"},{"key":"e_1_2_1_15_1","first-page":"203","article-title":"Distribution of HHV\u20106 variants in human tissues","volume":"5","author":"Di Luca D","year":"1996","journal-title":"Infect Agents Dis"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.299"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(93)90112-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119989"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00390-1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310703"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91580-4"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199605)49:1<34::AID-JMV6>3.0.CO;2-L"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200081"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.7.982"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200006270-00015"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.1.287-299.1990"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199511000-00013"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.4.651-653.1989"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.6.2173-2177.2001"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81962-6"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2876520"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65385-8"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105023241818"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91893-4"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042207"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.21143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.21143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T23:54:51Z","timestamp":1696722891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.21143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,21]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/jmv.21143"],"URL":"https:\/\/doi.org\/10.1002\/jmv.21143","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,21]]}}}