{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:03:30Z","timestamp":1763661810425},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Viral hepatitis ranks as the fifth cause of morbidity for infectious diseases in Cuba. Epidemics are observed frequently in the population, the hepatitis A virus being the main agent responsible for such epidemics. Previous reports also confirmed the circulation of the hepatitis E virus. From 1998 to 2003, 258 serum samples were collected by the Reference Laboratory on Viral Hepatitis during 33 outbreaks of acute viral hepatitis as well as from 39 sporadic clinical cases. Sera were tested for anti\u2010HAV and anti\u2010HEV IgM by EIA. Overall of the 33 outbreaks studied sera from 12 (36.4%) were positive for anti\u2010HAV IgM only, from 7 (21.2%) were positive for anti\u2010HEV IgM only, and from 14 (42.4%) were positive for antibodies to both viruses. Individually of the 258 sera collected, 137 (53.1%) were positives for anti\u2010HAV IgM, 20 (7.8%) were positives for anti\u2010HEV IgM, 33 (12.8%) were positives for both markers and 68 (26.4%) were negative to both. Of the clinical cases, 4 (10.3%) were positives for anti\u2010HAV IgM, 13 (33.3%) were positives for anti\u2010HEV IgM and 5 (12.8%) were positives for both markers. Seventeen (43.6%) sera were negatives for all viral hepatitis markers available (A\u2013E). A high positivity for HEV was found in outbreaks tested with the kit produced by CIGB. In particular HEV seems to infect individuals of all ages. The results demonstrate the co\u2010circulation of and co\u2010infection with two enterically transmitted viruses; however a higher positivity was observed for anti\u2010HAV than to anti\u2010HEV (53.1% vs. 7.8%) in outbreaks. J. Med. Virol. 80:798\u2013802, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21147","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T23:19:00Z","timestamp":1206141540000},"page":"798-802","source":"Crossref","is-referenced-by-count":40,"title":["Dual infection with hepatitis A and E viruses in outbreaks and in sporadic clinical cases: Cuba 1998\u20132003"],"prefix":"10.1002","volume":"80","author":[{"given":"Licel de los Angeles","family":"Rodr\u00edguez Lay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Caridad 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