{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:43:49Z","timestamp":1758631429711},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T00:00:00Z","timestamp":1208736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the JCV excretion in urine of 113 healthy Polish donors was analyzed. A 215\u2010bp region of the viral gene coding for a major capsid protein VP1 was PCR\u2010amplified and detected in 52 individuals (46.0%). The occurrence rate increased with age and was highest in the group of over 60\u2010year\u2010old donors (63.6%). Sequence analysis of the VP1 gene fragment revealed the following distribution of JCV genotypes in the investigated group: 1A, 31 (59.6%); 1B, 13 (25.0%); 2A, 2 (3.8%); and 2C, 6 samples (11.5%). The frequency and distribution of the JCV genotypes in the Polish population resembles that in other European countries, with the most abundant genotype 1 (84.6%). However, while in those countries the second most frequent genotype was usually 4, in the investigated group genotype 4 was not detected. J. Med. Virol. 80:1079\u20131083, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.21153","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T17:25:30Z","timestamp":1208798730000},"page":"1079-1083","source":"Crossref","is-referenced-by-count":15,"title":["Occurrence rate and genotype distribution of the JC virus (JCV) in a sample from the Polish population"],"prefix":"10.1002","volume":"80","author":[{"given":"Dariusz","family":"Kmieciak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szymon","family":"D\u0119bicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw 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